Investigation and Analysis of Clinical Application of Rivaroxaban in 191 Patients with Non-Valvular Atrial Fibrillation

XIE Cheng; LYU Lingyan; HANG Yongfu; ZHU Jianguo

doi:10.14009/j.issn.1672-2124.2020.08.019

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Investigation and Analysis of Clinical Application of Rivaroxaban in 191 Patients with Non-Valvular Atrial Fibrillation

更新时间：2022-10-08

- Investigation and Analysis of Clinical Application of Rivaroxaban in 191 Patients with Non-Valvular Atrial Fibrillation
- Vol. 20, Issue 8, Pages: 969-971(2020)
- 作者机构：
  
  1. 苏州大学附属第一医院药学部
  2. 江阴市人民医院药学部
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.08.019
  CLC： R541.75;R95
- Published：2020，
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[1]谢诚,吕玲燕,杭永付,朱建国.191例住院非瓣膜性心房颤动患者利伐沙班应用情况调查与分析[J].中国医院用药评价与分析,2020,20(08):969-971+975.

XIE Cheng, LYU Lingyan, HANG Yongfu, et al. Investigation and Analysis of Clinical Application of Rivaroxaban in 191 Patients with Non-Valvular Atrial Fibrillation. [J]. 20(8):969-971(2020)
[1]谢诚,吕玲燕,杭永付,朱建国.191例住院非瓣膜性心房颤动患者利伐沙班应用情况调查与分析[J].中国医院用药评价与分析,2020,20(08):969-971+975. DOI： 10.14009/j.issn.1672-2124.2020.08.019.

XIE Cheng, LYU Lingyan, HANG Yongfu, et al. Investigation and Analysis of Clinical Application of Rivaroxaban in 191 Patients with Non-Valvular Atrial Fibrillation. [J]. 20(8):969-971(2020) DOI： 10.14009/j.issn.1672-2124.2020.08.019.

摘要

目的:了解住院非瓣膜性心房颤动患者利伐沙班的临床应用现状

为其合理使用提供参考。方法:回顾性收集2018年8月至2019年12月入住苏州大学附属第一医院（以下简称"我院"）心血管内科使用利伐沙班的非瓣膜性心房颤动患者资料

根据药品说明书和相关指南或共识要求

对其适应证、禁忌证、用法及用量、联合用药、药物转换以及药品不良反应/事件等进行统计分析。结果:共有191例患者使用了利伐沙班

其中14例（占7.33%）为无适应证用药

12例（占6.28%）存在禁忌证;给药剂量不足的有93例（占48.69%）

给药剂量过大的有9例（占4.71%）

给药频次不合理的有13例（占6.81%）

与其他抗凝血药转换不合理的有20例（占21.98%）。结论:我院心血管内科住院非瓣膜性心房颤动患者利伐沙班的临床应用现状与相关要求仍存在一定差距

以给药剂量不足最为常见

而合并冠心病患者的不合理用药情况更为复杂。药师应积极参与该类患者的药物治疗

进一步规范利伐沙班的临床应用。

Abstract

OBJECTIVE:To investigate the clinical application status of rivaroxaban in inpatients with nonvalvular atrial fibrillation

so as to provide reference for the rational use.METHODS:Clinical data of inpatients with non-valvular atrial fibrillation in vasculocardiology department of the First Affiliated Hospital of Soochow University（hereinafter referred to as "our hospital"） from Aug.2018 to Dec.2019 were retrospectively extracted.Statistical analysis was performed on indications

contraindications

usage and dosage

drug combination

drug conversion

and adverse drug reactions/events.RESULTS:A total of 191 patients were treated with rivaroxaban

among which 14 cases（7.33%） had no indications and 12 cases（6.28%） had contraindications.There were 93 cases（48.69%） with insufficient dose

9 cases（4.71%） with excessive dose

13 cases（6.81%） with irrational drug frequency

and 20 cases（21.98%） with irrational conversion with other anticoagulants.CONCLUSIONS:There is still a certain gap between the clinical application status and relevant requirements of rivaroxaban in inpatients with non-valvular atrial fibrillation invasculocardiology department of our hospital

in which the insufficient dose of rivaroxaban is the most common

and the irrational application of rivaroxaban in patients associated with coronary heart disease is more complicated.Pharmacists should actively participate in the drug therapy of these patients and further standardize the clinical application of rivaroxaban.

关键词

利伐沙班非瓣膜性心房颤动临床应用

Keywords

RivaroxabanNon-valvular atrial fibrillationClinical application

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