Effects of Milrinone on Pulmonary Oxygen Function and Pulmonary Circulation Dynamics in Neonates

GAO Ning; WANG Pengchun; CUI Yanbin; Yang Mei

doi:10.14009/j.issn.1672-2124.2020.08.015

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Effects of Milrinone on Pulmonary Oxygen Function and Pulmonary Circulation Dynamics in Neonates

更新时间：2022-10-08

- Effects of Milrinone on Pulmonary Oxygen Function and Pulmonary Circulation Dynamics in Neonates
- Vol. 20, Issue 8, Pages: 953-956(2020)
- 作者机构：
  
  1. 保定市第一中心医院新生儿科
  2. 保定市第三中心医院急诊科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.08.015
  CLC： R722.1
- Published：2020，
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[1]高宁,王蓬春,崔艳滨,杨梅.米力农对新生儿肺氧合功能及肺循环动力学的影响[J].中国医院用药评价与分析,2020,20(08):953-956.

GAO Ning, WANG Pengchun, CUI Yanbin, et al. Effects of Milrinone on Pulmonary Oxygen Function and Pulmonary Circulation Dynamics in Neonates. [J]. 20(8):953-956(2020)
[1]高宁,王蓬春,崔艳滨,杨梅.米力农对新生儿肺氧合功能及肺循环动力学的影响[J].中国医院用药评价与分析,2020,20(08):953-956. DOI： 10.14009/j.issn.1672-2124.2020.08.015.

GAO Ning, WANG Pengchun, CUI Yanbin, et al. Effects of Milrinone on Pulmonary Oxygen Function and Pulmonary Circulation Dynamics in Neonates. [J]. 20(8):953-956(2020) DOI： 10.14009/j.issn.1672-2124.2020.08.015.

摘要

目的:探讨米力农对新生儿肺氧合功能及肺循环动力学的影响。方法:研究时间为2017年10月至2018年12月

选取保定市第一中心医院新生儿科收治的新生儿持续性肺动脉高压住院患者100例为研究对象

按照随机数字表法分为观察组和对照组

每组50例。对照组患儿给予常规药物治疗以及呼吸机支持

观察组患儿在此基础上联合米力农治疗。比较两组患儿两大血管间压力阶差（ΔP）、肺循环血流量/体循环血流量（QP/QS）、每博指数（SI）、心脏指数（CI）、左心室射血分数（LVEF）、左心室短轴缩短率（LVFS）、二尖瓣E峰和A峰比值（E/A）、氧合功能（OI）、肺动脉压力、全肺阻力、主动脉血氧饱和度水平及不良反应发生情况的差异。结果:治疗后

观察组患儿ΔP、SI及CI明显高于对照组

QP/QS明显低于对照组

差异均有统计学意义（P<0.05）。治疗后

两组患儿LVEF、LVFS、E/A及OI较治疗前呈不同程度升高;而观察组患儿LVEF、LVFS、E/A及OI明显高于对照组

差异有统计学意义（P<0.05）。与治疗前相比

两组患儿治疗后肺动脉压力、全肺阻力呈不同程度降低

主动脉血氧饱和度呈不同程度升高;治疗后

观察组患儿肺动脉压力、全肺阻力及主动脉血氧饱和度明显优于对照组

差异均有统计学意义（P<0.05）。结论:对于新生儿持续性肺动脉高压

在机械通气等常规治疗基础上联合米力农治疗可改善患儿的心功能

提高患儿的肺氧合功能

增加肺循环动力。

Abstract

OBJECTIVE:To probe into the effects of milrinone on pulmonary oxygen function and pulmonary circulation dynamics in neonates.METHODS:Totally 100 newborn hospitalized children with pulmonary hypertension admitted into the Department of Neonatology

Baoding the First Central Hospital from Oct.2017 to Dec.2018 were extracted to be divided into the observation group and the control group via the random number table

with 50 cases in each group.The control group was treated with routine drug therapy and ventilator support

and the observation group received milrinone based on the control group.Pressure difference between the two major vessels（ΔP）

pulmonary circulation blood flow/systemic circulation blood flow（QP/QS）

stroke index（SI）

cardiac index（CI）

left ventricular ejection fraction（LVEF）

left ventricular short axis reduced rate（LVFS）

mitral valve and A E peak ratio（E/A）

oxygenation function（OI）

pulmonary artery pressure and total pulmonary resistance

aortic blood oxygen saturation level and adverse drug reactions of two groups were compared.RESULTS:After treatment

the indexes ofΔP

SI and CI in the observation group were significantly higher than those in the control group

QP/QS was significantly lower than that in the control group

with statistically significant difference（P <0.05）.After treatment

the LVEF

LVFS

E/A and OI of two groups had been improved in different degrees

and the LVEF

LVFS

E/A and OI in the observation group were significantly higher than those in the control group

with statistically significant differences（P < 0.05）.Compared with before treatment

the pulmonary artery pressure and pulmonary resistance decreased in varying degrees

and the aortic oxygen saturation increased;after treatment

the pulmonary artery pressure

pulmonary resistance and aorta oxygen saturation were significantly better in the observation group than in the control group

the differences were statistically significant（P<0.05）.CONCLUSIONS:Conventional therapy such as mechanical ventilation combined with milrinone therapy in the treatment of persistent pulmonary hypertension can improve the heart function and the oxygenation function of children

and increase the power of pulmonary circulation.

关键词

米力农新生儿肺氧合功能肺循环动力学影响

Keywords

MilrinoneNeonatesPulmonary oxygenationPulmonary circulation dynamicsEffects

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