OBJECTIVE:To probe into the application of rebamipide combined with triple therapy in conservative treatment of acute perforation of gastroduodenal ulcer with positive Helicobacter pylori（Hp）.METHODS:105 patients with acute perforation of Hp-positive gastroduodenal ulcer admitted into Deyang People’s Hospita from Oct.2015 to Dec.2019 were selected and divided into research group（55 cases） and control group（50 cases） via random number table.Both groups were given conservative treatment

the control group was given triple therapy on that basis

while the research group was treated with ribapamide based on the control group.The clinical efficacy

hospitalization

HP eradication

ulcer healing

serum inflammatory factors [tumor necrosis factor α（TNF-α）

interleukin-6（IL-6） ]and gastrointestinal hormones [gastrin（Gas）

pepsinogen Ⅰ（PGⅠ）

pepsinogen Ⅱ（PGⅡ） ] levels before and after treatment of both groups were observed

differences in incidences of adverse drug reactions during study were recorded and compared.RESULTS:The total effective rate of research group was 94.55%（52/55）

which was significantly higher than that of the control group（82.00%

41/50）

with statistically significant difference（P < 0.05）.The remission time of clinical symptom

gastrointestinal decompression time and hospital stays of research group were significantly shorten than those of the control group

with statistically significant differences（P < 0.05）.The Hp eradication rate of research group was 90.91%（50/55）

which was significantly higher than that of the control group（76.00%

38/50）;the ulcer healing rate of research group was 87.27%（48/55）

which was significantly higher than that of the control group（68.00%

34/50）

with statistically significant differences（P<0.05）.After treatment

the serum TNF-α and IL-6 levels of both groups had been significantly decreased

and those of the research group were significantly lower than the control group;after treatment

the Gas

PGⅠ and PGⅡ levels of both groups had been significantly increased

and those of the research group were significantly higher than the control group

with statistically significant differences（P<0.05）.The incidences of adverse drug reactions of research group and control group were respectively 9.09%（5/55） and 12.00%（6/50）

the difference had no statistical significance（P >0.05）.CONCLUSIONS:The combination of rebamipide and triple therapy can significantly relieve inflammatory reaction in conservative treatment of acute perforation of Hp-positive gastroduodenal ulcer

improve gastrointestinal function

promote ulcer healing and Hp eradication

shorten the remission time clinical symptom

gastrointestinal decompression time and hospital stays

with definite efficacy and certain clinical value.