Research on Influencing Factors of Serum Valproic Acid Concentration/Dose Ratio in Patients with Epilepsy

ZENG Xiaoyun; LIN Ziqi; GE Bingchen; QUE Fuchang; ZHOU Benjie

doi:10.14009/j.issn.1672-2124.2020.08.005

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Research on Influencing Factors of Serum Valproic Acid Concentration/Dose Ratio in Patients with Epilepsy

更新时间：2022-10-08

- Research on Influencing Factors of Serum Valproic Acid Concentration/Dose Ratio in Patients with Epilepsy
- Vol. 20, Issue 8, Pages: 914-916(2020)
- 作者机构：
  
  1. 中山大学附属第七医院药学部
  2. 广东医科大学药学院
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.08.005
  CLC： R742.1
- Published：2020，
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[1]曾晓云,林子琦,葛冰琛,阙富昌,周本杰.丙戊酸在癫痫患者中的血清药物浓度/剂量比影响因素研究[J].中国医院用药评价与分析,2020,20(08):914-916+919.

ZENG Xiaoyun, LIN Ziqi, GE Bingchen, et al. Research on Influencing Factors of Serum Valproic Acid Concentration/Dose Ratio in Patients with Epilepsy. [J]. 20(8):914-916(2020)
[1]曾晓云,林子琦,葛冰琛,阙富昌,周本杰.丙戊酸在癫痫患者中的血清药物浓度/剂量比影响因素研究[J].中国医院用药评价与分析,2020,20(08):914-916+919. DOI： 10.14009/j.issn.1672-2124.2020.08.005.

ZENG Xiaoyun, LIN Ziqi, GE Bingchen, et al. Research on Influencing Factors of Serum Valproic Acid Concentration/Dose Ratio in Patients with Epilepsy. [J]. 20(8):914-916(2020) DOI： 10.14009/j.issn.1672-2124.2020.08.005.

摘要

目的:研究癫痫患者的性别、年龄、体重、联合用药及合并疾病对丙戊酸血清浓度/剂量比（concentration/dose

C/D）的影响。方法:回顾性分析2018年5月至2019年8月某院进行丙戊酸血清浓度监测的癫痫患者77例

将性别、年龄、体重、联合用药、合并疾病、日剂量和血清药物浓度等信息录入Excel表

计算C/D值

采用SPSS 22.0软件进行统计分析。结果:年龄<6岁、6～<12岁、12～<18岁、18～<60岁及≥60岁患者的丙戊酸C/D分别为（192.80±106.44）、（113.37±53.36）、（64.77±33.67）（60.34±23.82）及（84.80±21.50） ng·d/（mg·ml）

差异有统计学意义（P<0.05）。体重<22 kg、22～35 kg及>35 kg患者的丙戊酸C/D分别为（176.41±114.75）、（134.61±43.76）及（63.12±27.26） ng·d/（mg·ml）

差异有统计学意义（P<0.05）。而性别、联合用药及合并疾病对丙戊酸C/D无影响。结论:<12岁（尤其<6岁）的儿童以及体重≤35 kg的患者

需适当减少丙戊酸剂量

谨防发生不良反应。

Abstract

OBJECTIVE:To investigate the effects of gender

age

weight

drug combination and concomitant disease on serum drug concentration/dose ratio（C/D） of valproic acid in patients with epilepsy.METHOD:77 patients with epilepsy who were monitored for serum drug concentration of valproic acid in a certain hospital from May2018 to Aug.2019 were retrospectively analyzed.Information including gender

age

weight

drug combination

concomitant disease

daily dose and serum drug concentration were entered into the Excel table to calculate C/D values.SPSS 22.0 was adopted to conduct statistical analysis.RESULTS:The C/D values of patients aged <6 years

6-<12 years

12-< 18 years

18-< 60 years

≥60 years were respectively（192.80 ± 106.44）

（113.37 ± 53.36）

（64.77±33.67）

（60.34±23.82） and（84.80±21.50） ng·d/（mg·ml）

with statistically significant differences（P<0.05）.The C/D values of patients weighed <22 kg

22-35 kg and >35 kg were respectively（176.41±114.75）

（134.61±43.76） and（63.12±27.26） ng·d/（mg·ml）

with statistically significant differences（P<0.05）.Gender

drug combination and concomitant disease had no effects on the C/D values.CONCLUSIONS:Children age <12 years old（especially<6 years old） and patients weighed ≤35 kg need to reduce the dose of valproic acid appropriately to prevent adverse drug reactions.

关键词

丙戊酸血清药物浓度/剂量比影响因素年龄体重

Keywords

Valproic acidSerum drug concentration/dose ratioInfluencing factorAgeWeight

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