Retrospective Analysis of 656 Patients with Drug-induced Liver Injury

CHENG Yao; WANG Jinghong; XIA Kun; JIANG Jiming; ZHOU Huiping

doi:10.14009/j.issn.1672-2124.2020.07.030

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Retrospective Analysis of 656 Patients with Drug-induced Liver Injury

更新时间：2022-10-08

- Retrospective Analysis of 656 Patients with Drug-induced Liver Injury
- Vol. 20, Issue 7, Pages: 885-888(2020)
- 作者机构：
  
  中国中医科学院望京医院药学部
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.07.030
  CLC： R575
- Published：2020，
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[1]程遥,王景红,夏坤,蒋季明,周惠萍.656例药物性肝损伤病例的回顾性分析[J].中国医院用药评价与分析,2020,20(07):885-888.

CHENG Yao, WANG Jinghong, XIA Kun, et al. Retrospective Analysis of 656 Patients with Drug-induced Liver Injury. [J]. 20(7):885-888(2020)
[1]程遥,王景红,夏坤,蒋季明,周惠萍.656例药物性肝损伤病例的回顾性分析[J].中国医院用药评价与分析,2020,20(07):885-888. DOI： 10.14009/j.issn.1672-2124.2020.07.030.

CHENG Yao, WANG Jinghong, XIA Kun, et al. Retrospective Analysis of 656 Patients with Drug-induced Liver Injury. [J]. 20(7):885-888(2020) DOI： 10.14009/j.issn.1672-2124.2020.07.030.

摘要

目的:探讨导致药物性肝损伤（drug-induced liver injury

DILI）的药物种类、特点

为临床合理用药提供参考。方法:收集2010年1月至2019年6月中国中医科学院望京医院收治的656例DILI患者

对患者的临床资料进行统计分析。结果:656例DILI患者中

男性患者占59.0%（387例）

女性患者占41.0%（269例）

男性多于女性;发生DILI患者的原发疾病中

病例数排序居前5位的分别为感染性疾病、胃肠病、心血管疾病、皮肤病及风湿病;中西药联合应用导致DILI的占91.5%（600例）

单独使用西药导致的DILI占8.5%（56例）

涉及中草药、中成药、抗感染药、抗肿瘤药、激素类药物、心血管系统用药以及消化系统用药等。结论:本研究中

DILI在男性患者中的发病率较高

中草药及中成药、抗感染药、抗肿瘤药、激素类药物、心血管系统用药和非甾体抗炎药均会引起DILI

应引起临床足够重视

防止不良反应的发生。

Abstract

OBJECTIVE: To probe into the categories and characteristics of drugs leading to drug-induced liver injury（ DILI）

so as to provide references for clinical rational drug use.METHODS: Totally 656 patients with DILI admitted into Wangjing Hospital

China Academy of Chinese Medical Sciences from Jan.2010 to Jun.2019 were extracted.Statistical analysis was performed on clinical data of patients.RESULTS: Of the 656 patients with DILI

59.0%（ 387 cases） was male

41.0%（ 269 cases） was female

and more male than female.Among the primary diseases of DILI

infectious diseases

gastrointestinal diseases

cardiovascular diseases

skin diseases and rheumatism ranked the top 5.The drug combination of Chinese and Western medicine resulted in 91.5%（ 600 cases） of DILI

and8.5%（ 56 cases） of DILI caused by Western medicine alone

including Chinese herbal medicine

Chinese patent medicine

anti-infective drugs

anti-tumor drugs

hormone drugs

cardiovascular drugs and digestive drugs.CONCLUSIONS: In this study

the incidence of DILI in male patients is relatively high.Chinese herbal medicine and Chinese patent medicine

anti-infective drugs

anti-tumor drugs

hormonal drugs

cardiovascular drugs and digestive drugs can cause DILI

and clinical attention should be paid to prevent the occurrence of adverse drug reactions.

关键词

药物性肝损伤回顾性分析合理用药

Keywords

Drug-induced liver injuryRetrospective analysisRational drug use

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