OBJECTIVE: To systematically evaluate the efficacy and safety of Pudilan Xiaoyan oral liquid in the treatment of hand

foot and mouth disease in children

so as to provide evidence-based reference for clinic application.METHODS: CNKI

CBM

VIP database

Wanfang database

PubMed and the Cochrane Library were retrieved to collect the randomized controlled trials（ RCT） of Pudilan Xiaoyan oral liquid in the treatment of hand

foot and mouth disease in children [the study group was treated with Pudilan Xiaoyan oral liquid combined with conventional antiviral drugs in Western medicine

and the control group received conventional antiviral drugs in Western medicine alone; the outcome indicators include efficacy（ total effective rate of clinical treatment

duration of fever

disappearance time of herpes and ulcer） and safety（ adverse drug reactions）.Clinical data that met the inclusion criteria were extracted

and the quality was evaluated in accordance with Cochrane Handbook 5.1.0.RevMan 5.3 was used for Meta-analysis.RESULTS: Totally 20 literature were collected

including 2 182 patients.Meta-analysis results showed that the total effective rate（ RR = 1.18

95%CI = 1.14-1.22

P < 0.001）

the duration of fever（ MD =-1.39

95% CI =-1.61--1.16

P<0.001）

disappearance time of herpes（ MD =-1.91

95%CI =-2.20--1.63

P<0.001） and disappearance time of ulcer（ MD =-1.45

95%CI =-1.69--1.21

P<0.001） in the study group were significantly better than those in the control group

the differences were statistically significant.The incidence of adverse drug reactions was similar between two groups

with no statistically significant difference（ RR = 1.14

95% CI = 0.69-1.88

P > 0.001）.CONCLUSIONS: Pudilan Xiaoyan oral liquid combined with conventional antiviral drugs in Western medicine can improve the efficacy of children with hand

foot and mouth disease

and does not increase the incidence of adverse drug reactions

yet it still needs to be further verified by the large sample and high-quality randomized controlled study.