Evidence-based Evaluation of Shenfu Injection in the Treatment of Shock

ZHOU Shen; MEN Peng; JIANG Hua; LI Xiaoxiao; ZHAI Suodi; ZHAO Rongsheng; YANG Yiheng

doi:10.14009/j.issn.1672-2124.2020.07.019

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Evidence-based Evaluation of Shenfu Injection in the Treatment of Shock

更新时间：2022-10-08

- Evidence-based Evaluation of Shenfu Injection in the Treatment of Shock
- Vol. 20, Issue 7, Pages: 840-844(2020)
- 作者机构：
  
  1. 北京大学第三医院药剂科
  2. 北京大学医学部药物评价中心
  3. 北京市药学质量控制和改进中心
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.07.019
  CLC： R285.6
- Published：2020，
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[1]周燊,门鹏,江华,李潇潇,翟所迪,赵荣生,杨毅恒.参附注射液治疗休克的循证评价[J].中国医院用药评价与分析,2020,20(07):840-844.

ZHOU Shen, MEN Peng, JIANG Hua, et al. Evidence-based Evaluation of Shenfu Injection in the Treatment of Shock. [J]. 20(7):840-844(2020)
[1]周燊,门鹏,江华,李潇潇,翟所迪,赵荣生,杨毅恒.参附注射液治疗休克的循证评价[J].中国医院用药评价与分析,2020,20(07):840-844. DOI： 10.14009/j.issn.1672-2124.2020.07.019.

ZHOU Shen, MEN Peng, JIANG Hua, et al. Evidence-based Evaluation of Shenfu Injection in the Treatment of Shock. [J]. 20(7):840-844(2020) DOI： 10.14009/j.issn.1672-2124.2020.07.019.

摘要

目的:评价参附注射液治疗休克的有效性与安全性

为临床实践提供循证依据。方法:计算机检索PubMed、the Cochrane Library、中国知网、万方数据库和中国生物医学文献服务系统等数据库

收集参附注射液治疗休克的系统评价/荟萃分析（Meta分析）

由2名评价者根据纳入与排除标准筛选文献、提取资料和评价质量后

对证据进行综合梳理与分析。结果:共纳入7篇系统评价/Meta分析

方法学质量中等。有效性方面

与单独应用常规治疗相比

参附注射液联合常规治疗可明显提高有效率（未区分类型的休克患者:OR=2.35

95%CI=1.52～3.65;心源性休克患者:OR=3.21

95%CI=1.70～6.06;急性心肌梗死合并心源性休克患者:OR=0.35

95%CI=0.20～0.57）

明显提高用药6 h后平均动脉压（感染性休克患者:SMD=0.82

95%CI=0.03～1.61）

明显降低用药6 h后血乳酸水平（感染性休克患者:SMD=-0.51

95%CI=-0.70～-0.32）

明显降低用药6 h后心率（感染性休克患者:SMD=-0.90

95%CI=-1.47～-0.33）

并明显降低死亡率

上述差异均有统计学意义。安全性方面的数据均未作统计学差异分析。结论:在常规治疗基础上联合应用参附注射液

可提高休克治疗（包括感染性休克和心源性休克等）的有效性

并降低死亡率

但安全性比较数据不足

未来应进一步开展高质量临床研究予以验证。

Abstract

OBJECTIVE: To evaluate the efficacy and safety of Shenfu injection in the treatment of shock

so as to provide evidence-based evidence for clinical practice.METHODS: PubMed

the Cochrane Library

CNKI

Wanfang database and SinoMed database were systematically retrieved to collect the systematic review/Meta-analysis of Shenfu injection in the treatment of shock.Two reviewers screened the literature

extracted the data and evaluated the quality according to the inclusion and exclusion criteria

and then comprehensively sorted out and analyzed the evidence.RESULTS: Totally 7 systematic reviews/Meta-analyses were enrolled.The methodology was of medium quality.In terms of effectiveness

compared with conventional therapy

Shenfu injection combined with conventional therapy could improve the efficiency（ patients with undifferentiated shock: OR = 2.35

95%CI = 1.52-3.65; patients with cardiogenic shock: OR = 3.21

95%CI = 1.70-6.06; patients with acute myocardial infarction and cardiogenic shock: OR = 0.35

95%CI = 0.20-0.57）

improve the mean arterial pressure after 6 h of administration（ patients with septic shock: SMD =0.82

95%CI = 0.03-1.61）

reduce the blood lactate value after 6 h of administration（ patients with septic shock:SMD =-0.51

95%CI =-0.70--0.32）

reduce the heart rate after 6 h of administration（ patients with septic shock:SMD =-0.90

95% CI =-1.47--0.33） and reduce the mortality

with statistically significant differences.Data on safety were not analyzed statistically.CONCLUSIONS: Combined with Shenfu injection on the basis of conventional therapy can improve the effectiveness of shock treatment（ including septic shock and cardiogenic shock） and reduce the mortality.Yet the comparative safety data are insufficient

and further high-quality clinical studies should be conducted to validate the results.

关键词

参附注射液休克有效性安全性循证评价

Keywords

Shenfu injectionShockEfficacySafetyEvidence-based evaluation

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