OBJECTIVE: To probe into the physical stability of finished infusion of ginkgo leaf extract and dipyridamole injection within 8 h

so as to provide reference for clinical safety and rational use.METHODS: According to the drug instructions and clinical dosage

ginkgo leaf extract and dipyridamole injection was prepared

and physical properties such as appearance

pH

particles and osmotic pressure of finished infusion were investigated after 0

2

4 and8 h.RESULTS: Ginkgo leaf extract and dipyridamole injection was the smallest and stable in 0.9% sodium chloride injection.The particles were large and unstable in 5%/10% glucose injection.In terms of osmotic pressure

the osmotic pressure of this drug was the largest in 10% glucose injection

and the osmotic pressure of finished infusion diluted with5% glucose injection and 0.9% sodium chloride injection was closer to that of human body.The changes of the pH in three kinds of infusions were basically the same

and the pH at each time point met the requirements.The physical properties were stable within 2 h after the preparation

and changed sharply 2 h after preparation.CONCLUSIONS: In the clinical use of ginkgo leaf extract and dipyridamole injection

0.9% sodium chloride injection is recommended as the diluent for the reduction of adverse events.If the patient has electrolyte requirements

it is recommended to use 5%glucose injection as dilution.Yet 10% glucose injection is not recommended as the solvent.In terms of the time limit for administration

it is recommended to use up within 2 h after drug preparation.