Efficacy of Cytidine Diphosphate Choline Combined with Monosialotetrahexosylganglioside Sodium in the Treatment of Neonatal Hypoxic-Ischemic Encephalopathy

WU Xinting; BIAN Weini; ZHENG Lingfang; CHANG Pan; HE Wei; JIA Nan

doi:10.14009/j.issn.1672-2124.2020.07.005

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Efficacy of Cytidine Diphosphate Choline Combined with Monosialotetrahexosylganglioside Sodium in the Treatment of Neonatal Hypoxic-Ischemic Encephalopathy

更新时间：2022-10-08

- Efficacy of Cytidine Diphosphate Choline Combined with Monosialotetrahexosylganglioside Sodium in the Treatment of Neonatal Hypoxic-Ischemic Encephalopathy
- Vol. 20, Issue 7, Pages: 785-787(2020)
- 作者机构：
  
  1. 西安医学院第二附属医院新生儿科
  2. 西安医学院第二附属医院中心实验室
  3. 西安医学院医学技术系
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.07.005
  CLC： R742
- Published：2020，
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[1]吴新婷,卞伟妮,郑玲芳,常盼,何薇,贾南.胞二磷胆碱联合单唾液酸四己糖神经节苷脂钠治疗新生儿缺氧缺血性脑病的疗效观察[J].中国医院用药评价与分析,2020,20(07):785-787+791.

WU Xinting, BIAN Weini, ZHENG Lingfang, et al. Efficacy of Cytidine Diphosphate Choline Combined with Monosialotetrahexosylganglioside Sodium in the Treatment of Neonatal Hypoxic-Ischemic Encephalopathy. [J]. 20(7):785-787(2020)
[1]吴新婷,卞伟妮,郑玲芳,常盼,何薇,贾南.胞二磷胆碱联合单唾液酸四己糖神经节苷脂钠治疗新生儿缺氧缺血性脑病的疗效观察[J].中国医院用药评价与分析,2020,20(07):785-787+791. DOI： 10.14009/j.issn.1672-2124.2020.07.005.

WU Xinting, BIAN Weini, ZHENG Lingfang, et al. Efficacy of Cytidine Diphosphate Choline Combined with Monosialotetrahexosylganglioside Sodium in the Treatment of Neonatal Hypoxic-Ischemic Encephalopathy. [J]. 20(7):785-787(2020) DOI： 10.14009/j.issn.1672-2124.2020.07.005.

摘要

目的:探讨胞二磷胆碱联合单唾液酸四己糖神经节苷脂钠治疗新生儿缺氧缺血性脑病（neonatal hypoxic-ischemic encephalopathy

NHIE）的疗效。方法:选取2017年3月至2019年3月西安医学院第二附属医院收治的NHIE患儿114例

根据随机数字表法将患儿分为研究组（n=57）、对照组（n=57）。对照组患儿给予单唾液酸四己糖神经节苷脂钠治疗

研究组患儿在对照组的基础上加用胞二磷胆碱治疗。比较两组患儿的临床疗效

基质金属蛋白酶9（MMP-9）、胰岛素生长因子1（IGF-1）、Tau蛋白（Tau）和脂联素（APN）水平

智力发育指数（mental development index

MDI）评分、运动发育指数（psychomotor development index

PDI）评分及不良反应发生情况。结果:研究组患儿治疗2周后的临床总有效率为80.70%（46/57）

明显高于对照组的59.65%（34/57）

差异有统计学意义（P<0.05）。两组患儿治疗2周后的MMP-9、Tau水平较治疗前明显降低

IGF-1、APN水平较治疗前明显升高;研究组患儿治疗2周后的MMP-9、Tau水平明显低于对照组

而IGF-1、APN水平则明显高于对照组

差异均有统计学意义（P<0.05）。两组患儿末次随访时MDI评分、PDI评分均较治疗前明显升高

且研究组患儿明显高于对照组

差异均有统计学意义（P<0.05）。对照组、研究组患儿的不良反应发生率分别为5.26%（3/57）、7.02%（4/57）

差异无统计学意义（P>0.05）。结论:胞二磷胆碱联合单唾液酸四己糖神经节苷脂钠治疗NHIE的疗效确切

可有效改善患儿智力及运动发育状况

改善血清MMP-9、Tau、IGF-1及APN等因子水平

且用药安全性较好

临床应用价值较高。

Abstract

OBJECTIVE: To probe into the efficacy of cytidine diphosphate choline combined with monosialotetrahexosylganglioside sodium（ GM1） in the treatment of neonatal hypoxic-ischemic encephalopathy（ NHIE）.METHODS: Totally 114 children with NHIE admitted into the Second Affiliated Hospital of Xi’an Medical University from Mar.2017 to Mar.2019 were extracted to be divided into the stydy group（ n = 57） and the control group（ n = 57） via the random number table.The control group was treated with GM1

while the study group received cytidine diphosphate choline based on the study group.The clinical efficacy

matrix metalloproteinase-9（ MMP-9）

insulin growth factor-1（ IGF-1） levels

Tau protein（ Tau）

adiponectin（ APN）

mental development index（ MDI）

psychomotive development index（ PDI） score and adverse drug reactions of two groups were compared.RESULTS:The total clinical effective rate of the study group after treatment of two weeks was 80.70%（ 46/57）

significantly higher than that of the control group 59.65%（ 34/57）

the difference was statistically significant（ P < 0.05）.After treatment of two weeks

MMP-9 and Tau in two groups were lower than those before treatment

the levels of IGF-1 and APN were higher than those before treatment（ P<0.05）.After treatment of two weeks

the levels of MMP-9 and Tau in the study group were significantly lower than those in the control group

while the levels of IGF-1 and APN were significantly higher than those in the control group

the differences were statistically significant（ P<0.05）.At the last follow-up

MDI and PDI scores in both groups were significantly higher than those before treatment

and the study group was significantly higher than the control group

with statistically significant differences（ P < 0.05）.The incidence of adverse drug reactions in the control group and the study group were 5.26%（ 3/57） and 7.02%（ 4/57）

respectively

the difference was not statistically significant（ P > 0.05）.CONCLUSIONS: The efficacy of cytidine diphosphate choline combined with GM1 in the treatment of NHIE is significant

which can effectively improve the intelligence and motor development of children

improve the levels of MMP-9

Tau

IGF-1

APN and other factors

with higher safety and clinical application value.

关键词

胞二磷胆碱单唾液酸四己糖神经节苷脂钠新生儿缺氧缺血性脑病疗效

Keywords

Cytidine diphosphate cholineMonosialotetrahexosylganglioside sodiumNeonatalHypoxic-ischemic encephalopathyEfficacy

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