Retrospective Study of 978 Cases of Serum Digoxin Concentration Monitoring

HE Xin; PENG Danyihui; WANG Jingjing; WANG Honglin; QIAN Yiyi

doi:10.14009/j.issn.1672-2124.2020.07.003

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Retrospective Study of 978 Cases of Serum Digoxin Concentration Monitoring

更新时间：2022-10-08

- Retrospective Study of 978 Cases of Serum Digoxin Concentration Monitoring
- Vol. 20, Issue 7, Pages: 778-780(2020)
- 作者机构：
  
  1. 云南省阜外心血管病医院药剂科
  2. 昆明医科大学第一附属医院临床药学科
  3. 昆明医科大学药学院云南省天然药物药理重点实验室
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.07.003
  CLC： R972
- Published：2020，
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[1]何昕,彭丹一慧,王晶晶,王红琳,钱懿轶.978例地高辛血药浓度监测回顾性研究[J].中国医院用药评价与分析,2020,20(07):778-780+784.

HE Xin, PENG Danyihui, WANG Jingjing, et al. Retrospective Study of 978 Cases of Serum Digoxin Concentration Monitoring. [J]. 20(7):778-780(2020)
[1]何昕,彭丹一慧,王晶晶,王红琳,钱懿轶.978例地高辛血药浓度监测回顾性研究[J].中国医院用药评价与分析,2020,20(07):778-780+784. DOI： 10.14009/j.issn.1672-2124.2020.07.003.

HE Xin, PENG Danyihui, WANG Jingjing, et al. Retrospective Study of 978 Cases of Serum Digoxin Concentration Monitoring. [J]. 20(7):778-780(2020) DOI： 10.14009/j.issn.1672-2124.2020.07.003.

摘要

目的:探讨地高辛血药浓度（serum digoxin concentration

SDC）的影响因素

为临床合理用药提供参考。方法:回顾性分析2013年1月至2018年1月昆明医科大学第一附属医院收治的978例患者的稳态SDC监测结果

采用χ

检验分析性别、年龄、肌酐清除率（creatinine clearance rate

Ccr）及联合用药种类等对SDC分布和中毒反应的影响

并纳入有相关性的因素进行Logistic回归分析。结果:χ

检验结果显示

Ccr对SDC分布和中毒反应有明显影响

年龄对SDC分布有明显影响

性别和联合用药种类对中毒反应有明显影响（P

0.05）。Logistic回归分析结果显示

Ccr对SDC分布有显著影响

性别、联合用药种类及SDC水平对中毒反应有显著影响（P

0.05）。结论:SDC和中毒反应个体差异较大且影响因素较多

应监测SDC和临床表现并制订个体化给药方案

确保药物治疗安全、有效。

Abstract

OBJECTIVE: To investigate the influencing factors of serum digoxin concentration（ SDC） monitoring

and to provide reference for rational drug use in clinic.METHODS: Retrospective analysis was performed on results of 978 cases with steady-state SDC monitoring in the First Affiliated Hospital of Kunming Medical University from Jan.2013 to Jan.2018.Effects of gender

age

creatinine clearance rate（ Ccr） and types of drug combination on SDC distribution and toxic response were analyzed by Chi-squared test

and relevant factors were included in Logistic regression analysis.RESULTS: Chi-square tests showed that SDC distribution and toxic response could be significantly affected by Ccr

SDC distribution could also be affected by age

toxic response could be affected by gender and types of drug combination（ P < 0.05）.Logistic regression analysis revealed that SDC distribution could be significantly influenced by Ccr

and toxic response could also be significantly influenced by gender

types of drug combination and level of SDC（ P<0.05）.CONCLUSIONS: The individual differences between SDC and toxic response are large and there are many influencing factors.SDC and clinical manifestations should be monitored and individualized

drug administration regimen should be formulated to ensure the safety and effectiveness of drug therapy.

关键词

地高辛血药浓度监测回顾性研究

Keywords

DigoxinSerum concentration monitoringRetrospective study

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