Retrospective Analysis of 927 Children with Adverse Drug Reaction

LIU Renfeng; ZHOU Lifang; JIANG Yun; ZHOU Chenyi

doi:10.14009/j.issn.1672-2124.2020.06.029

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Retrospective Analysis of 927 Children with Adverse Drug Reaction

更新时间：2022-10-08

- Retrospective Analysis of 927 Children with Adverse Drug Reaction
- Vol. 20, Issue 6, Pages: 749-751(2020)
- 作者机构：
  
  苏州大学附属儿童医院药剂科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.06.029
  CLC： R969
- Published：2020，
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[1]柳仁凤,周丽芳,蒋云,周辰怡.927例儿童药品不良反应回顾性分析[J].中国医院用药评价与分析,2020,20(06):749-751+755.

LIU Renfeng, ZHOU Lifang, JIANG Yun, et al. Retrospective Analysis of 927 Children with Adverse Drug Reaction. [J]. 20(6):749-751(2020)
[1]柳仁凤,周丽芳,蒋云,周辰怡.927例儿童药品不良反应回顾性分析[J].中国医院用药评价与分析,2020,20(06):749-751+755. DOI： 10.14009/j.issn.1672-2124.2020.06.029.

LIU Renfeng, ZHOU Lifang, JIANG Yun, et al. Retrospective Analysis of 927 Children with Adverse Drug Reaction. [J]. 20(6):749-751(2020) DOI： 10.14009/j.issn.1672-2124.2020.06.029.

摘要

目的:了解苏州大学附属儿童医院（以下简称"我院"）儿童药品不良反应（adverse drug reaction

ADR）发生的特点和规律

为儿童临床安全用药提供参考。方法:采用回顾性分析方法

对2017-2018年我院收集到的927例ADR报告

分别从患儿性别、年龄、给药途径、原患疾病、涉及药物种类、ADR累及器官和（或）系统、临床表现以及临床转归等方面进行统计分析。结果:927例发生ADR的患儿中

男性623例（占67. 21%）

女性304例（占32. 79%）;婴幼儿较多

共579例（占62. 46%）。静脉给药引发的ADR居多

共607例（占65. 48%）

其中婴幼儿346例（占37. 32%）。呼吸系统用药引发的ADR最多

共588例（占63. 43%）

发生ADR的婴幼儿的原患疾病也以呼吸系统疾病为主。化学药引发的ADR病例数居首位

共796例（占85. 87%）。ADR累及器官和（或）系统共974例次

主要累及皮肤及其附件（632例次

占64. 89%）

其中婴幼儿的临床表现以皮疹居多。ADR的临床转归良好

无死亡病例。结论:临床上应重点加强对儿童ADR的监测与上报

促进儿童临床合理用药

进一步减少和预防儿童ADR的发生。

Abstract

OBJECTIVE: To investigate the characteristics and laws of adverse drug reaction（ ADR） in children in Children’s Hospital of Soochow University（ hereinafter referred to as "our hospital"）

so as to provide reference for children’s safe medication in clinic. METHODS: Retrospective analysis method was adopted

statistical analysis was conducted on 927 reports of ADR collected in our hospital from 2017 to 2018

including gender

age

route of administration

primary disease

type of drugs involved

ADR involvement of organs and（ or） systems

clinical manifestations and clinical outcomes. RESULTS: Of the 927 children who developed ADR

623 cases were male（ 67. 21%） and 304 cases were female（ 32. 79%）. There were more infants and young children

with a total of579 cases（ 62. 46%）. ADR caused by intravenous administration was the most

totally 607 cases（ 65. 48%）

including 346 infants and young children（ 37. 32%）. Respiratory system drugs caused the most ADR

totally 588 cases（ 63. 43%）

and the primary disease of infants and young children who developed ADR was mainly respiratory disease. The number of ADR cases caused by chemical drugs ranked first

with a total of 796 cases（ 85. 87%）. There were 974 case-times of ADR involving organs and（ or） systems

mainly involving skin and its accessories（ 632 casetimes

64. 89%）

and the clinical manifestations of infants and young children were mostly skin rash. The clinical outcome of ADR was good and there were no deaths. CONCLUSIONS: In clinical practice

it is necessary to strengthen the monitoring and reporting of ADR in children

so as to promote rational drug use in children and further reduce and prevent the occurrence of ADR.

关键词

药品不良反应合理用药儿童

Keywords

Adverse drug reactionRational drug useChildren

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