Evaluation of Application of Antibiotics in Chronic Obstructive Pulmonary Disease

DAI Rouli; LI Xin

doi:10.14009/j.issn.1672-2124.2020.06.018

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Evaluation of Application of Antibiotics in Chronic Obstructive Pulmonary Disease

更新时间：2022-10-08

- Evaluation of Application of Antibiotics in Chronic Obstructive Pulmonary Disease
- Vol. 20, Issue 6, Pages: 709-711(2020)
- 作者机构：
  
  1. 南京医科大学第四附属医院医务部
  2. 南京医科大学药学院临床药学系
  3. 南京医科大学医政学院
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.06.018
  CLC： R95
- Published：2020，
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[1]戴柔丽,李歆.慢性阻塞性肺疾病抗菌药物使用状况评价研究[J].中国医院用药评价与分析,2020,20(06):709-711+715.

DAI Rouli, LI Xin. Evaluation of Application of Antibiotics in Chronic Obstructive Pulmonary Disease. [J]. 20(6):709-711(2020)
[1]戴柔丽,李歆.慢性阻塞性肺疾病抗菌药物使用状况评价研究[J].中国医院用药评价与分析,2020,20(06):709-711+715. DOI： 10.14009/j.issn.1672-2124.2020.06.018.

DAI Rouli, LI Xin. Evaluation of Application of Antibiotics in Chronic Obstructive Pulmonary Disease. [J]. 20(6):709-711(2020) DOI： 10.14009/j.issn.1672-2124.2020.06.018.

摘要

目的:探讨慢性阻塞性肺疾病（chronic obstructive pulmonary disease

COPD）患者抗菌药物使用情况及治疗情况。方法:选取2017—2019年在南京医科大学第四附属医院（以下简称"我院"）进行治疗的983例COPD患者的临床资料进行回顾性分析

统计分析抗菌药物使用种类、金额、药物利用指数（drug utilization index

DUI）及限定日费用（daily drug cost

DDC）等。结果:983例患者治疗过程中抗菌药物使用率为100%

其中使用1种抗菌药物的有735例

二联用药的有187例

三联用药的有52例

四联用药的有9例;每例患者平均使用抗菌药物（2. 35±0. 68）种;抗菌药物使用金额平均为（1 573. 9±17. 52）元;第3代头孢菌素、氟喹诺酮类抗菌药物的使用率较高

分别为33. 7%（331例）和25. 7%（253例）; DUI在1. 0±0. 1范围内的有左氧氟沙星、头孢噻肟、头孢哌酮舒巴坦和氟康唑; DDC排序居前5位的分别为替考拉宁、亚胺培南西司他丁、哌拉西林他唑巴坦、头孢西丁和头孢噻肟。结论:我院COPD治疗中抗菌药物的使用基本合理

但仍有可以改进的空间

需要进一步完善医院抗菌药物使用管理制度。

Abstract

OBJECTIVE: To investigate the application status and treatment process of antibiotics in chronic obstructive pulmonary disease（ COPD）. METHODS: Retrospective analysis was conduced on clinical data of 983 patients with COPD from the Fourth Affiliated Hospital of Nanjing Medical University（ hereinafter referred to as "our hospital"） from 2017 to 2019. Categories

consumption sum

drug utilization index（ DUI） and daily drug cost（ DDC） were statistically analyzed. RESULTS: During the treatment

the application rate of antibiotics in 983 patients was 100%

among which 735 patients were given one kind of antibiotics

187 patients were given two kinds of antibiotics

52 patients were given three kinds of antibiotics and 9 patients were given four kinds of antibiotics. The average number of antibiotics used in each patient was 2. 35±0. 68. The average consumption sum of antibiotics used was（ 1 573. 9±17. 52） yuan. The third generation cephalosporins and quinolones accounted for 33. 7%（ n = 331） and25. 7%（ n = 253） of the total antibiotics used in our hospital. DUIs in the range of 1. 0 ± 0. 1 were respectively levofloxacin

cefotaxime

cefoperazone sulbactam and fluconazole. The top five drugs ranked by DDC were respectively teicoplanin

imipenemcilastatin

piperacillintazobactam

cefoxitin and cefotaxime. CONCLUSIONS: The application of antibiotics in the treatment of COPD in our hospital is basically reasonable

but there is still room for improvement

and the management system of application of antibiotics in the hospital needs to be further improved.

关键词

抗菌药物使用情况慢性阻塞性肺疾病

Keywords

AntibioticsApplication statusChronic obstructive pulmonary disease

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