Research on Molecular Mechanism of Shaofu Zhuyu Decoction in the Treatment of Primary Dysmenorrhea Based on Integrated Pharmacology Platform V2. 0

GAO Hongjie; LI Jun; GONG Leilei

doi:10.14009/j.issn.1672-2124.2020.06.012

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Research on Molecular Mechanism of Shaofu Zhuyu Decoction in the Treatment of Primary Dysmenorrhea Based on Integrated Pharmacology Platform V2. 0

更新时间：2022-10-08

- Research on Molecular Mechanism of Shaofu Zhuyu Decoction in the Treatment of Primary Dysmenorrhea Based on Integrated Pharmacology Platform V2. 0
- Vol. 20, Issue 6, Pages: 682-684(2020)
- 作者机构：
  
  1. 中国中医科学院中医药信息研究所
  2. 中国中医科学院西苑医院检验科
  3. 首都医科大学附属北京妇产医院药事部
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.06.012
  CLC： R285
- Published：2020，
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[1]高宏杰,李君,贡磊磊.基于整合药理学平台V2.0的少腹逐瘀汤治疗原发性痛经分子机制研究[J].中国医院用药评价与分析,2020,20(06):682-684+688.

GAO Hongjie, LI Jun, GONG Leilei. Research on Molecular Mechanism of Shaofu Zhuyu Decoction in the Treatment of Primary Dysmenorrhea Based on Integrated Pharmacology Platform V2. 0. [J]. 20(6):682-684(2020)
[1]高宏杰,李君,贡磊磊.基于整合药理学平台V2.0的少腹逐瘀汤治疗原发性痛经分子机制研究[J].中国医院用药评价与分析,2020,20(06):682-684+688. DOI： 10.14009/j.issn.1672-2124.2020.06.012.

GAO Hongjie, LI Jun, GONG Leilei. Research on Molecular Mechanism of Shaofu Zhuyu Decoction in the Treatment of Primary Dysmenorrhea Based on Integrated Pharmacology Platform V2. 0. [J]. 20(6):682-684(2020) DOI： 10.14009/j.issn.1672-2124.2020.06.012.

摘要

目的:基于整合药理学平台V2. 0探讨少腹逐瘀汤治疗原发性痛经的分子机制。方法:通过整合药理学平台V2. 0收集少腹逐瘀汤中药成分及其相关靶标、痛经疾病靶标。借助平台分析药物靶标和疾病靶标之间的相互作用关系

构建"中药-疾病核心靶标"网络

最后通过中医药关联网络挖掘模块构建"中药-成分-靶标-通路"多维网络。结果:共收集少腹逐瘀汤9味中药的352种化学成分和1 903个药物靶标

筛选获得痛经15个疾病靶标。药物和疾病靶标分析结果显示

共有3个共有靶标（PPARG、PTGS2及CYP17A1）;可视化网络分析结果表明

少腹逐瘀汤中的槲皮素、异鼠李素及丁香油酚等成分可能通过作用于ESR1、CNR1及CALM1等靶标参与多巴胺受体、e NOS活化和VEGFA-VEGFR2通路等通路发挥治疗原发性痛经作用。结论:基于整合药理学平台V2. 0构建了少腹逐瘀汤与原发性痛经的核心靶标网络和多维可视化网络

为少腹逐瘀汤治疗原发性痛经的研究提供了重要参考

也为临床应用提供了理论依据。

Abstract

OBJECTIVE: To research the molecular mechanism of Shaofu Zhuyu decoction in the treatment of primary dysmenorrhea based on Integrated Pharmacology Platform V2. 0. METHODS: To collect the traditional Chinese medicine components of Shaofu Zhuyu decoction and its related targets and dysmenorrhea disease targets through the Integrated Pharmacology Platform V2. 0

so as to analyze the interaction between drug targets and disease targets

to establish a "Chinese medicine-disease core target"network and finally construct a "Chinese medicine-componenttarget-pathway"multidimensional network through the TCM related network mining module. RESULTS: A total of 352 chemical components and 1 903 drug targets of 9 categories of Chinese herbs in Shaofu Zhuyu decoction were collected

15 disease targets of dysmenorrhea were obtained after screening. Results of drug and disease target analysis showed that there were 3 common targets（ PPARG

PTGS2 and CYP17 A1）; results of visual network analysis indicated that quercetin

isorhamnetin and eugenol in Shaofu Zhuyu decoction may participate in pathways of dopamine receptor

eNOS activation and VEGFA-VEGFR2 pathway by acting on targets of ESR1

CNR1 and CALM1

so that play the role in the treatment of primary dysmenorrhea. CONCLUSIONS: The core target network and multidimensional visual network of Shaofu Zhuyu decoction and primary dysmenorrhea are constructed Based on the Integrated Pharmacology Platform V2. 0

which provides an important reference for the research of Shaofu Zhuyu decoction in the treatment of primary dysmenorrhea

and also provides a theoretical basis for clinical application.

关键词

整合药理学平台V2. 0少腹逐瘀汤原发性痛经分子机制

Keywords

Integrated Pharmacology Platform V2.0Shaofu Zhuyu decoctionPrimary dysmenorrheaMolecular mechanism

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