Efficacy of Rifampicin Capsule（ Ⅱ ） in the Treatment of Tuberculosis and its Effects on Imageological Changes

TAO Lei; ZHAO Zhiren; ZHANG Letian

doi:10.14009/j.issn.1672-2124.2020.06.010

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Efficacy of Rifampicin Capsule（ Ⅱ ） in the Treatment of Tuberculosis and its Effects on Imageological Changes

更新时间：2022-10-08

- Efficacy of Rifampicin Capsule（ Ⅱ ） in the Treatment of Tuberculosis and its Effects on Imageological Changes
- Vol. 20, Issue 6, Pages: 675-677(2020)
- 作者机构：
  
  1. 河北省胸科医院结核五科
  2. 河北省胸科医院急诊科
  3. 河北省胸科医院呼吸二科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.06.010
  CLC： R521
- Published：2020，
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[1]陶磊,赵志忍,张乐天.利福平胶囊(Ⅱ)治疗肺结核的疗效及对患者影像学变化的影响[J].中国医院用药评价与分析,2020,20(06):675-677.

TAO Lei, ZHAO Zhiren, ZHANG Letian. Efficacy of Rifampicin Capsule（ Ⅱ ） in the Treatment of Tuberculosis and its Effects on Imageological Changes. [J]. 20(6):675-677(2020)
[1]陶磊,赵志忍,张乐天.利福平胶囊(Ⅱ)治疗肺结核的疗效及对患者影像学变化的影响[J].中国医院用药评价与分析,2020,20(06):675-677. DOI： 10.14009/j.issn.1672-2124.2020.06.010.

TAO Lei, ZHAO Zhiren, ZHANG Letian. Efficacy of Rifampicin Capsule（ Ⅱ ） in the Treatment of Tuberculosis and its Effects on Imageological Changes. [J]. 20(6):675-677(2020) DOI： 10.14009/j.issn.1672-2124.2020.06.010.

摘要

目的:探讨利福平胶囊（Ⅱ）治疗肺结核的临床疗效及对患者影像学变化的影响。方法:按照随机数字表法将河北省胸科医院于2018年3—12月收治的130例肺结核患者分为观察组和对照组

每组65例。所有患者均为初治涂阳患者

均采用2HRZE/4HR（H:异烟肼; R:利福平; Z:吡嗪酰胺; E:乙胺丁醇）的常规化疗方案

其中观察组患者给予利福平胶囊（Ⅱ）

对照组患者给予利福平胶囊。比较两组患者的临床疗效、痰菌转阴情况、影像学变化情况及不良反应发生情况的差异。结果:观察组患者的总有效率明显高于对照组[93. 85%（61/54） vs. 78. 46%（51/65）]

差异有统计学意义（P<0. 05）。治疗2、4及6个月后

观察组患者的痰涂片转阴率明显高于对照组

差异均有统计学意义（P<0. 05）。观察组患者病灶吸收有效率、空洞闭合有效率分别为86. 15%（56/65）、93. 85%（61/65）

明显高于对照组的64. 62%（42/65）、78. 46%（51/65）

差异均有统计学意义（P<0. 05）。观察组患者的不良反应发生率为13. 85%（9/65）

明显低于对照组的33. 85%（22/65）

差异有统计学意义（χ2=7. 159

P=0. 007）。结论:利福平胶囊（Ⅱ）治疗治疗肺结核的疗效确切

可促进病灶吸收及空洞闭合

且安全性高。

Abstract

OBJECTIVE: To probe into the clinical efficacy of rifampicin capsule（ Ⅱ） in the treatment of tuberculosis and its effects on imageological changes. METHODS: A total of 130 patients with tuberculosis admitted into Hebei Provincial Chest Hospital from Mar. to Dec. 2018 were divided into observation group and control group via random number table

with 65 cases in each group. All the patients were initial sputum-smear positive and treated with conventional chemotherapy of 2 HRZE/4 HR（ H: isoniazid; R: rifampin; Z: pyrazinamide; E: ethambutol）

of which the observation group was given rifampicin capsule（ Ⅱ）

while the control group was given rifampicin capsule. Differences in clinical efficacy

negative-conversion rates of sputum bacterium

imageological changes and incidences of adverse drug reactions were compared between two groups. RESULTS: The total effective rate of observation group was significantly higher than that of the control group [93. 85%（ 61/54） vs. 78. 46%（ 51/65） ]

with statistically significant difference（ P < 0. 05）. At 2

4 and 6 months after treatment

the negative-conversion rates of sputum bacterium of observation group was significantly higher than that of the control group

with statistically significant difference（ P<0. 05）. The effective rates of lesion absorption and cavity closure were respectively 86. 15%（ 56/65）and 93. 85%（ 61/65）

which were significantly higher than those of the control group [64. 62%（ 42/65） and78. 46%（ 51/65） ]

with statistically significant differences（ P < 0. 05）. The incidence of adverse drug reactions of observation group was 13. 85%（ 9/65）

which was significantly lower than that of the control group（ 33. 85%

22/65）

with statistically significant difference（ χ2= 7. 159

P = 0. 007）. CONCLUSIONS: The efficacy of rifampicin capsule（ Ⅱ） in the treatment of tuberculosis is remarkable

which can promote lesion absorption and cavity closure

with high safety.

关键词

利福平胶囊（Ⅱ）肺结核影像学疗效

Keywords

Rifampicin capsule（Ⅱ）TuberculosisImageologicalEfficacy

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