OBJECTIVE: To probe into the clinical efficacy of Xiaoer Dingchuan oral liquid combined with recombinant human interferon α1 b in the treatment of bronchiolitis in children. METHODS: 198 children with bronchiolitis admitted into the First People’s Hospital of Jingmen from Mar. 2016 to Mar. 2019 were selected and divided into control group and research group via random number table

with 99 cases in each group. The control group was treated with recombinant human interferon α1 b

while the research group was given Xiaoer Dingchuan oral liquid based on the control group. Differences in clinical efficacy

immunologic function indicators

serological indicator

disappearance time or remission time of clinical symptoms were compared between two groups

incidences of adverse drug reactions of two groups were recorded. RESULTS: After 7-day treatment

the total effective rate of research group was 81. 82%（ 81/99）

which was significantly higher than that of the control group（ 67. 68%

67/99）

with statistically significant difference（ P<0. 05）. After 7-day treatment

the immune globulin G

immune globulin A and immune globulin M levels of both groups had been significantly increased

and those of the research group were significantly higher than the control group

with statistically significant differences（ P<0. 05）. The disappearance time of cough and rale

remission time of wheeze and duration of fever of research group were significantly shorter than those of the control group

with statistically significant differences（ P < 0. 05）. After 7-day treatment

the procalcitonin

monocyte chemoattractant protein-1 and interleukin-6 levels of both groups had been significantly decreased

and those of the research group were significantly lower than the control group; the interferon-γ levels of both groups had been significantly improved

and that of the research group was significantly higher than the control group

with statistically significant differences（ P<0. 05）. The incidences of adverse drug reactions of research group and control group were respectively 22. 22%（ 22/99） and 19. 19%（ 19/99）

the difference had no statistical significance（ P > 0. 05）.CONCLUSIONS: The efficacy of Xiaoer Dingchuan oral liquid combined with recombinant human interferon α1 b in the treatment of bronchiolitis in children

which can rapidly improve clinical symptoms

effectively promote body immunity and serological indicator

with good safety.