Clinical Research on Qingresanjie Capsule Combined with Ganciclovir Ophthalmic Gel in the Treatment of Epidemic Keratoconjunctivitis

HUANG Yanling; LIU Hongke

doi:10.14009/j.issn.1672-2124.2020.06.006

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Clinical Research on Qingresanjie Capsule Combined with Ganciclovir Ophthalmic Gel in the Treatment of Epidemic Keratoconjunctivitis

更新时间：2022-10-08

- Clinical Research on Qingresanjie Capsule Combined with Ganciclovir Ophthalmic Gel in the Treatment of Epidemic Keratoconjunctivitis
- Vol. 20, Issue 6, Pages: 660-662(2020)
- 作者机构：
  
  成都市第五人民医院眼科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.06.006
  CLC： R772.21
- Published：2020，
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[1]黄滟凌,刘洪科.清热散结胶囊联合更昔洛韦眼用凝胶治疗流行性角结膜炎的临床研究[J].中国医院用药评价与分析,2020,20(06):660-662+666.

HUANG Yanling, LIU Hongke. Clinical Research on Qingresanjie Capsule Combined with Ganciclovir Ophthalmic Gel in the Treatment of Epidemic Keratoconjunctivitis. [J]. 20(6):660-662(2020)
[1]黄滟凌,刘洪科.清热散结胶囊联合更昔洛韦眼用凝胶治疗流行性角结膜炎的临床研究[J].中国医院用药评价与分析,2020,20(06):660-662+666. DOI： 10.14009/j.issn.1672-2124.2020.06.006.

HUANG Yanling, LIU Hongke. Clinical Research on Qingresanjie Capsule Combined with Ganciclovir Ophthalmic Gel in the Treatment of Epidemic Keratoconjunctivitis. [J]. 20(6):660-662(2020) DOI： 10.14009/j.issn.1672-2124.2020.06.006.

摘要

目的:探讨清热散结胶囊联合更昔洛韦眼用凝胶治疗流行性角结膜炎的临床疗效。方法:选取2018年4月至2019年4月成都市第五人民医院就诊的流行性角结膜炎患者90例

依照随机数字表法分为对照组和观察组

每组45例。对照组患者采用更昔洛韦眼用凝胶治疗

观察组患者给予清热散结胶囊联合更昔洛韦眼用凝胶治疗

两组患者均连续治疗14 d。观察两组患者的临床疗效

治疗前后中医证候评分、角膜上皮下浸润评分（corneal subepithelial infiltrate scores

CSIS）、视力及泪液乳铁蛋白（LF）、总蛋白（TP）及溶菌酶（LZM）水平

记录并比较两组患者治疗过程中不良反应的发生情况。结果:观察组患者的临床总有效率为97. 78%（44/45）

明显高于对照组的86. 67%（39/45）

差异有统计学意义（P<0. 05）。治疗后

两组患者视力水平明显优于治疗前

CSIS评分、各项中医证候评分明显低于治疗前;同时

观察组患者治疗后视力水平明显优于对照组

CSIS评分、各项中医证候评分明显低于对照组

上述差异均有统计学意义（P<0. 05）。治疗后

两组患者泪液LF、TP及LZM水平明显高于治疗前

同时观察组患者LF、TP及LZM水平明显高于对照组

上述差异均有统计学意义（P<0. 05）。治疗期间

观察组、对照组患者不良反应发生率分别为4. 44%（2/45）、13. 32%（6/45）

差异无统计学意义（P>0. 05）。结论:清热散结胶囊联合更昔洛韦眼用凝胶治疗流行性角结膜炎的临床疗效明确

有助于减轻临床症状和角膜损伤

改善视力

且安全性较好。

Abstract

OBJECTIVE: To probe into the clinical efficacy of Qingresanjie capsule combined with ganciclovir ophthalmic gel in the treatment of epidemic keratoconjunctivitis. METHODS: 90 patients with epidemic keratoconjunctivitis admitted into the Fifth People’s Hospital of Chengdu from Apr. 2018 to Apr. 2019 were selected and divided into control group and observation group via random number table

with 45 cases in each group. The control group was treated with ganciclovir ophthalmic gel

while the observation group was given Qingresanjie capsule combined with ganciclovir ophthalmic gel

both groups were treated for 14 days. The clinical efficacy

TCM syndrome scores

corneal subepithelial infiltrate scores（ CSIS）

eyesight and tear lactoferrin（ LF）

total protein（ TP） and lysozyme（ LZM） levels of the two groups before and after treatment were observed

the incidences of adverse drug reactions of the two groups were recorded and compared. RESULTS: The total clinical effective rate of observation group was 97. 78%（ 44/45）

which was significantly higher than that of the control group（ 86. 67%

39/45）

with statistically significant difference（ P<0. 05）. After treatment

the eyesight levels of both groups had been improved

the CSIS and various TCM syndrome scores were significantly lower than those of before treatment; after treatment

the eyesight of observation group was significantly better than that of the control group

while the CSIS and various TCM syndrome scores were significantly lower than those of the control group

with statistically significant differences（ P <0. 05）. After treatment

the tear LF

TP and LZM levels of both groups were significantly higher than those of before treatment

and LF

TP and LZM levels of the observation group was significantly higher than the control group

with statistically significant differences（ P<0. 05）. During treatment

the incidences of adverse drug reactions of observation group and control group were respectively 4. 44%（ 2/45） and 13. 32%（ 6/45）

the difference had no statistical significance（ P>0. 05）. CONCLUSIONS: The efficacy of Qingresanjie capsule combined with ganciclovir ophthalmic gel in the treatment of epidemic keratoconjunctivitis is remarkable

which is helpful to relieve clinical symptoms and corneal injury

improve eyesight

with good safety.

关键词

流行性角结膜炎清热散结胶囊更昔洛韦眼用凝胶疗效

Keywords

Epidemic keratoconjunctivitisQingresanjie capsuleGanciclovir ophthalmic gelEfficacy

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