OBJECTIVE: To probe into whether the gene polymorphism of adenylate cyclase is associated with the clinical response of drug therapy for patients with bipolar mania at acute stage. METHODS: Totally 103 patients diagnosed with bipolar mania at acute stage admitted into Xuzhou Dongfang People’s Hospital and 60 healthy volunteers from May 2016 to Jan. 2019 were selected. The patients were interviewed with Bech-Rafaelsen mania rating scale（BRMS） and CGI-BP-S before enrolled

the alleles of rs2230739 locus in ADCY2 gene of the two groups were detected. The patients were given lithium carbonate combined with quetiapine for treatment

the BRMS and treatment emergent symptom scale（TESS） scores of patients were observed before and after treatment. According to different genotypes

the BRMS scores of patients after treatment were analyzed. RESULTS: Two types of alleles（G and A）were detected at the rs2230739 locus in ADCY2 gene

including three genotypes（GG

GA and AA）. There was no statistical significance in difference in genotypes between bipolar mania group and healthy volunteer group（χ

2

= 3. 949

P = 0. 139）. At 2

4 and 8 weeks after treatment

the BRMS score of patients were significantly lower than that of before treatment

with statistically significant differences（t = 36. 483

P = 0. 000; t = 45. 772

P = 0. 000; t = 11. 005

P = 0. 000）. After 8-week treatment

the total effective was 93. 2%（96/103）. After 2-week treatment

the differences in BRMS scores among three genotypes were statistically significant（F = 4. 410

P = 0. 015）

of which the difference in BRMS scores between GG type and GA type was statistically significant（P = 0. 004）. After 4-week treatment

the differences in BRMS scores among three genotypes were statistically significant（F = 4. 819

P = 0. 010）

of which the differences in BRMS scores between GG type and GA type（P = 0. 004）

GG type and AA type（P = 0. 047） were statistically significant. After 8-week treatment

the differences in BRMS scores among three genotypes were statistically significant（F = 5. 289

P = 0. 007）

of which the differences in BRMS scores between GG type and GA type（P =0. 002）

GG type and AA type（P = 0. 047） were statistically significant. CONCLUSIONS: The efficacy of lithium carbonate combined with quetiapine in treatment of bipolar mania at acute stag is remarkable

which is associated with the polymorphism of rs2230739 locus in ADCY2 gene

and the susceptibility of the three genotypes to lithium carbonate and quetiapine is GG type

>

GA type

>

AA type.