Efficacy of Sanwei Longdanhua Tablets Combined with Cefetamet Pivoxil Hydrochloride Tablets in the Treatment of Acute Laryngitis and its Effect on Serum Inflammatory Factor Levels

ZHANG Jing; LI Peng; LI Hui; HUANG Jing

doi:10.14009/j.issn.1672-2124.2020.05.011

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Efficacy of Sanwei Longdanhua Tablets Combined with Cefetamet Pivoxil Hydrochloride Tablets in the Treatment of Acute Laryngitis and its Effect on Serum Inflammatory Factor Levels

更新时间：2022-10-08

- Efficacy of Sanwei Longdanhua Tablets Combined with Cefetamet Pivoxil Hydrochloride Tablets in the Treatment of Acute Laryngitis and its Effect on Serum Inflammatory Factor Levels
- Vol. 20, Issue 5, Pages: 551-553(2020)
- 作者机构：
  
  1. 武汉市普仁医院耳鼻咽喉头颈外科
  2. 武汉亚心总医院普外科
  3. 武汉市普仁医院中医针灸科
  4. 武汉市普仁医院护理部
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.05.011
  CLC： R766.5
- Published：2020，
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[1]张静,李鹏,李辉,黄静.三味龙胆花片联合盐酸头孢他美酯片治疗急性咽喉炎的疗效及对血清炎症因子水平的影响[J].中国医院用药评价与分析,2020,20(05):551-553.

ZHANG Jing, LI Peng, LI Hui, et al. Efficacy of Sanwei Longdanhua Tablets Combined with Cefetamet Pivoxil Hydrochloride Tablets in the Treatment of Acute Laryngitis and its Effect on Serum Inflammatory Factor Levels. [J]. 20(5):551-553(2020)
[1]张静,李鹏,李辉,黄静.三味龙胆花片联合盐酸头孢他美酯片治疗急性咽喉炎的疗效及对血清炎症因子水平的影响[J].中国医院用药评价与分析,2020,20(05):551-553. DOI： 10.14009/j.issn.1672-2124.2020.05.011.

ZHANG Jing, LI Peng, LI Hui, et al. Efficacy of Sanwei Longdanhua Tablets Combined with Cefetamet Pivoxil Hydrochloride Tablets in the Treatment of Acute Laryngitis and its Effect on Serum Inflammatory Factor Levels. [J]. 20(5):551-553(2020) DOI： 10.14009/j.issn.1672-2124.2020.05.011.

摘要

目的:探讨三味龙胆花片联合盐酸头孢他美酯片治疗急性咽喉炎的疗效及对血清炎症因子水平的影响。方法:选取2016年10月至2019年10月武汉市普仁医院收治的急性咽喉炎患者120例

采用随机数字表法将患者分为观察组及对照组

每组60例。对照组患者口服盐酸头孢他美酯片治疗

观察组患者在对照组的基础上口服三味龙胆花片。观察两组患者的临床疗效、症状减退或消失时间、血清炎症因子[超敏C反应蛋白（hs-CRP）、白细胞介素1β（IL-1β）、白细胞介素6（IL-6）及肿瘤坏死因子α（TNF-α）]水平及不良反应发生情况。结果:观察组患者的总有效率为96. 7%（58/60）

明显高于对照组的88. 3%（53/60）

差异有统计学意义（χ

=10. 421

0. 05）。观察组患者咽喉痛消失时间、发热减退时间、咽喉异物感消失时间及咽喉黏膜充血消失时间明显短于对照组

差异均有统计学意义（t分别为8. 544、9. 542、7. 254及8. 545

P均

0. 05）。与治疗前相比

两组患者治疗后hs-CRP、IL-1β、IL-6及TNF-α表达水平明显降低

差异均有统计学意义（P

0. 05）;与对照组相比

观察组患者治疗后hs-CRP、IL-1β、IL-6及TNF-α表达水平明显降低

差异均有统计学意义（P

0. 05）。观察组、对照组患者的不良反应发生率分别为1. 7%（1/60）、3. 3%（2/60）

差异无统计学意义（χ

=1. 494

0. 05）。结论:三味龙胆花片联合盐酸头孢他美酯片治疗

可以明显提高急性咽喉炎患者的疗效

并降低患者血清炎症因子表达水平。

Abstract

OBJECTIVE: To probe into the efficacy of Sanwei Longdanhua tablets combined with Cefetamet pivoxil hydrochloride tablets in the treatment of acute laryngitis and its effect on serum inflammatory factor levels. METHODS:Totally 120 patients with acute laryngitis admitted into Wuhan Puren Hospital from Oct. 2016 to Oct. 2019 were selected and divided into observation group and control group via random number table

with 60 cases in each group. The control group were treated with Cefetamet pivoxil hydrochloride tablets

while the observation group was given Sanwei Longdanhua tablets based on the control group. The clinical efficacy

remission or disappearance times of symptoms

serum inflammatory factor levels [hypersensitive C-reactive protein（hs-CRP）

interleukin-1β（IL-1β）

interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） ]and incidences of adverse drug reactions of both groups were observed.RESULTS: The total effective rate of observation group was 96. 7%（58/60）

which was significantly higher than that of the control group（88. 3%

53/60）

with statistically significant difference（χ

= 10. 421

0. 05）. The disappearance time of sore throat

remission time of fever

disappearance times of foreign body sensation and mucosal congestion in throat of observation group were significantly shorter than those of the control group

with statistically significant differences（t = 8. 544/9. 542/7. 254/8. 545

0. 05）. Compared with before treatment

the expression levels of hsCRP

IL-1β

IL-6 and TNF-α of both groups were significantly lower than those of after treatment

with statistically significant differences（P

0. 05）; compared with the control group

the expression levels of hs-CRP

IL-1β

IL-6 and TNF-α of observation group were significantly lower after treatment

with statistically significant differences（P

0. 05）.The incidences of adverse drug reactions of observation group and control group were respectively 1. 7%（1/60） and3. 3%（2/60）

the difference had no statistical significance（χ

= 1. 494

0. 05）. CONCLUSIONS: The combination of Sanwei Longdanhua tablets and Cefetamet pivoxil hydrochloride tablets can significantly improve the efficacy in the treatment of acute laryngitis

and reduce the expression levels of serum inflammatory factor.

关键词

三味龙胆花片盐酸头孢他美酯急性咽喉炎血清炎症因子

Keywords

Sanwei Longdanhua tabletsCefetamet pivoxil hydrochlorideAcute pharyngitisSerum inflammatory factor

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