Process of Clinical Molecular of Azacitidine and Decitabine in the Treatment of Hematological Tumors

YU Ning; TANG Yi’nan; ZHANG Lei

doi:10.14009/j.issn.1672-2124.2020.04.033

您当前的位置：

首页 >

文章列表页 >

Process of Clinical Molecular of Azacitidine and Decitabine in the Treatment of Hematological Tumors

更新时间：2022-10-08

- Process of Clinical Molecular of Azacitidine and Decitabine in the Treatment of Hematological Tumors
- Vol. 20, Issue 4, Pages: 510-512(2020)
- 作者机构：
  
  中日友好医院药学部
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.04.033
  CLC： R733
- Published：2020，
扫描看全文
[1]于宁,唐一楠,张镭.阿扎胞苷和地西他滨治疗血液系统肿瘤的临床分子学研究进展[J].中国医院用药评价与分析,2020,20(04):510-512.

YU Ning, TANG Yi’nan, ZHANG Lei. Process of Clinical Molecular of Azacitidine and Decitabine in the Treatment of Hematological Tumors. [J]. 20(4):510-512(2020)
[1]于宁,唐一楠,张镭.阿扎胞苷和地西他滨治疗血液系统肿瘤的临床分子学研究进展[J].中国医院用药评价与分析,2020,20(04):510-512. DOI： 10.14009/j.issn.1672-2124.2020.04.033.

YU Ning, TANG Yi’nan, ZHANG Lei. Process of Clinical Molecular of Azacitidine and Decitabine in the Treatment of Hematological Tumors. [J]. 20(4):510-512(2020) DOI： 10.14009/j.issn.1672-2124.2020.04.033.

摘要

核苷类药物阿扎胞苷和地西他滨目前被用于治疗急性髓系白血病（acute myeloid leukemia

AML）和骨髓增生异常综合征（myelodysplastic syndrome

MDS）

不仅适合于高强度的化疗

也应用于其余血液系统肿瘤和实体肿瘤。本文着重于讨论目前以核苷类药物阿扎胞苷和地西他滨为基础的治疗方案的成熟性问题

筛选、综述了超过10年的阿扎胞苷和地西他滨临床实践经验并探讨其分子学机制

以期为今后的临床研究提供依据。

Abstract

Azacytidine and desitabine are currently used in the treatment of acute myeloid leukemia（ AML） and myelodysplastic syndrome（ MDS）

not only for high-intensity chemotherapy but for tumors of the rest of the blood system and solid tumors. This paper focuses on the maturity of current treatment regimens based on azacytidine and descitabine

screens and reviews the clinical practice of azacytidine and descitabine for more than 10 years

and discusses the molecular mechanisms

so as to provide basis for future clinical research.

关键词

核苷阿扎胞苷地西他滨骨髓增生异常综合征急性髓系白血病去甲基化

Keywords

NucleosideAzacytidineDesitabineMyelodysplastic syndromeAcute myeloid leukemiaDemethylation

references

查看原文

Views

286

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Rapid Health Technology Assessment of Azacitidine in the Treatment of Myelodysplastic Syndrome

Related Author

SHEN Liucen

HUANG Lei

ZHANG Chunyan

SHEN Kai

Related Institution

Dept. of Pharmacy, Nantong Haimen People’s Hospital

Dept. of Pharmacy, Affiliated Hospital of Nantong University

⁰