OBJECTIVE: To investigate the application of proton pump inhibitor（ PPI） in Bozhou People ’s Hospital（ hereinafter referred to as "our hospital"）

so as to clarify the PPI specifications that need to be controlled

and provide relevant suggestions for clinical PPI selection. METHODS: To investigate the PPI consumption data of our hospital in 2018

the defined daily dose（ DDD） method and ABC-improved VEN method were adopted for statistical analysis

and to determine the group Ⅰ（ high）

group Ⅱ（ low） and group Ⅲ（ medium） based on the analysis results and management priorities. RESULTS: ABC-improved VEN method classified PPIs based on reducing patient burden and hospital costs

which was easy for management. There were 18 specifications of PPIs were involved

with the total consumption sum was 14 051 911. 21 yuan; of which the group Ⅰ included 5 specifications of AN-kind and DDD analysis

with the consumption sum was 9 405 764. 53 yuan（ 66. 94%）

represented by pantoprazole sodium for injection（ 40 mg） and rabeprazole sodium for injection（ 20 mg）; the group Ⅱ included 5 specifications of CV-kind

with the consumption sum was 886 138. 62 yuan（ 6. 31%）

represented by Omeprazole enteric-coated tablets（ 20 mg）; the group Ⅲ included 10 specifications

with the consumption sum was 3 760 008. 06 yuan（ 26. 76%）

represented by Omeprazole enteric-coated tablets（ 40 mg）. CONCLUSIONS: The construction of PPI application in our hospital is not rational

drugs of group Ⅰ should be monitored to reduce irrational medication

drugs of group Ⅲ is recommended to the clinic

and secure an adequate supply.