Efficacy of Kelu Oral Liquid Combined with Ketotifen in the Treatment of Cough Variant Asthma and its Effects on Immune Function and Inflammatory Factors

WU Xifeng; FENG Gaohua

doi:10.14009/j.issn.1672-2124.2020.04.009

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Efficacy of Kelu Oral Liquid Combined with Ketotifen in the Treatment of Cough Variant Asthma and its Effects on Immune Function and Inflammatory Factors

更新时间：2022-10-08

- Efficacy of Kelu Oral Liquid Combined with Ketotifen in the Treatment of Cough Variant Asthma and its Effects on Immune Function and Inflammatory Factors
- Vol. 20, Issue 4, Pages: 418-420(2020)
- 作者机构：
  
  张家港市中医医院呼吸与危重症医学科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.04.009
  CLC： R562.25
- Published：2020，
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[1]吴喜锋,冯高华.咳露口服液联合酮替芬治疗咳嗽变异性哮喘的疗效及对免疫功能、炎症因子水平的影响[J].中国医院用药评价与分析,2020,20(04):418-420+424.

WU Xifeng, FENG Gaohua. Efficacy of Kelu Oral Liquid Combined with Ketotifen in the Treatment of Cough Variant Asthma and its Effects on Immune Function and Inflammatory Factors. [J]. 20(4):418-420(2020)
[1]吴喜锋,冯高华.咳露口服液联合酮替芬治疗咳嗽变异性哮喘的疗效及对免疫功能、炎症因子水平的影响[J].中国医院用药评价与分析,2020,20(04):418-420+424. DOI： 10.14009/j.issn.1672-2124.2020.04.009.

WU Xifeng, FENG Gaohua. Efficacy of Kelu Oral Liquid Combined with Ketotifen in the Treatment of Cough Variant Asthma and its Effects on Immune Function and Inflammatory Factors. [J]. 20(4):418-420(2020) DOI： 10.14009/j.issn.1672-2124.2020.04.009.

摘要

目的:探讨咳露口服液联合酮替芬治疗咳嗽变异性哮喘的疗效及对免疫功能、炎症因子水平的影响。方法:选取2016年3月至2018年10月张家港市中医医院收治的咳嗽变异性哮喘患者150例

根据随机数字表法将患者分为对照组（n=75）和研究组（n=75）。对照组患者给予酮替芬治疗

研究组患者在对照组的基础上联合咳露口服液治疗。比较两组患者临床疗效、免疫功能、炎症因子[白细胞介素4（IL-4）、γ干扰素（IFN-γ）]水平、生活质量及不良反应发生情况的差异。结果:治疗2个月后

研究组患者的总有效率为72. 00%（54/75）

明显高于对照组的56. 00%（42/75）

差异有统计学意义（P <0. 05）。治疗2个月后

两组患者CD4+、CD4+/CD8+水平较治疗前明显升高

且研究组患者明显高于对照组;两组患者CD8+水平较治疗前明显降低

且研究组患者明显低于对照组

上述差异均有统计学意义（P <0. 05）。治疗2个月后

两组患者IL-4水平较治疗前明显降低

且研究组患者明显低于对照组;两组患者IFN-γ水平较治疗前明显升高

且研究组患者明显高于对照组

上述差异均有统计学意义（P <0. 05）。治疗2个月后

两组患者日常生活活动评分均较治疗前明显升高

且研究组患者明显高于对照组

差异均有统计学意义（P <0. 05）。对照组、研究组患者的不良反应发生率分别为16. 00%（12/75）、18. 67%（14/75）

差异无统计学意义（P=0. 666）。结论:咳露口服液联合酮替芬治疗咳嗽变异性哮喘的疗效显著

可有效改善机体免疫功能、炎症因子水平

且不增加不良反应发生概率

临床应用价值较高。

Abstract

OBJECTIVE: To probe into the efficacy of Kelu oral liquid combined with ketotifen in the treatment of cough variant asthma and its effects on immune function and inflammatory factors. METHODS: Totally 150 patients with cough variant asthma admitted into Zhangjiagang Traditional Chinese Medicine Hospital from Mar. 2016 to Oct. 2018 were extracted to be divided into the control group and the study group via the random number table

with 75 cases in each group. The control group was given ketotifen

while the study group additionally received Kelu oral liquid bases on the control group. The clinical efficacy

immune function

inflammatory factors [interleukin 4（ IL-4）

γ-interferon（ IFN-γ） ]levels

life quality

and incidence of adverse drug reactions of two groups were compared. RESULTS: After treatment of 2 months

the total effective rate of the study group was 72. 00%（ 54/75）

significantly higher than56. 00%（ 42/75） in the control group

the difference was statistically significant（ P < 0. 05）. After treatment of 2 months

the levels of CD4+

CD4+/CD8+in two groups were significantly higher than those before treatment

and the study group was significantly higher than that of the control group; the levels of CD8+were significantly lower than those before treatment

and the study group was significantly lower than the control group

the above differences were statistically significant（ P < 0. 05）. After treatment of 2 months

the levels of IL-4 in two groups were significantly lower than those before treatment

and the study group was significantly lower than the control group; the levels of IFN-γ in two groups were significantly higher than those before treatment

and the study group was significantly higher than the control group

with statistically significant differences（ P < 0. 05）. After treatment of 2 months

the activity of daily living scores in two groups were significantly higher than those before treatment

and the study group was significantly higher than the control group

with statistically significant differences（ P < 0. 05）. The incidence of adverse drug reactions in the control group and the study group were 16. 00%（ 12/75） and 18. 67%（ 14/75）

with no significant difference（ P = 0. 666）. CONCLUSIONS: The efficacy of Kelu oral liquid combined with ketotifen in the treatment of cough variant asthma is significant

can effectively improve the immune function and the levels of inflammatory factors without increasing the incidence of adverse drug reactions

and has higher clinical values.

关键词

咳露口服液酮替芬咳嗽变异性哮喘疗效生活质量

Keywords

Kelu oral liquidKetotifenCough variant asthmaEfficacyLife quality

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