Clinical Study on Bushen Tiaojing Recipe in the Treatment of Polycystic Ovary Syndrome of Kidney-Yin Deficiency

WANG Zhenzhi; WEN Jie; YU Chaoqin; CAI Qinhua

doi:10.14009/j.issn.1672-2124.2020.04.007

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Clinical Study on Bushen Tiaojing Recipe in the Treatment of Polycystic Ovary Syndrome of Kidney-Yin Deficiency

更新时间：2022-10-08

- Clinical Study on Bushen Tiaojing Recipe in the Treatment of Polycystic Ovary Syndrome of Kidney-Yin Deficiency
- Vol. 20, Issue 4, Pages: 411-413(2020)
- 作者机构：
  
  1. 上海市浦东新区中医医院妇科
  2. 第二军医大学长海医院中医妇科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.04.007
  CLC： R271.9
- Published：2020，
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[1]王针织,温洁,俞超芹,蔡勤华.补肾调经方治疗肾阴虚型多囊卵巢综合征的临床研究[J].中国医院用药评价与分析,2020,20(04):411-413+417.

WANG Zhenzhi, WEN Jie, YU Chaoqin, et al. Clinical Study on Bushen Tiaojing Recipe in the Treatment of Polycystic Ovary Syndrome of Kidney-Yin Deficiency. [J]. 20(4):411-413(2020)
[1]王针织,温洁,俞超芹,蔡勤华.补肾调经方治疗肾阴虚型多囊卵巢综合征的临床研究[J].中国医院用药评价与分析,2020,20(04):411-413+417. DOI： 10.14009/j.issn.1672-2124.2020.04.007.

WANG Zhenzhi, WEN Jie, YU Chaoqin, et al. Clinical Study on Bushen Tiaojing Recipe in the Treatment of Polycystic Ovary Syndrome of Kidney-Yin Deficiency. [J]. 20(4):411-413(2020) DOI： 10.14009/j.issn.1672-2124.2020.04.007.

摘要

目的:探讨上海市名老中医经验方——补肾调经方治疗肾阴虚型多囊卵巢综合征的临床疗效。方法:选取2017年1月至2019年3月上海市浦东新区中医医院收治的肾阴虚型多囊卵巢综合征患者60例作为研究对象

按照随机数字表法分为治疗组和对照组

每组30例。对照组患者给予枸橼酸氯米芬片口服治疗

治疗组患者给予补肾调经方口服治疗

均连续治疗6个月。观察两组患者临床疗效

黄体生成素（LH）、卵泡刺激素（FSH）、睾酮（T）、空腹血糖（FPG）及胰岛素（INS）水平的变化情况

采用胰岛素抵抗指数（HOMA-IR）评估患者胰岛素抵抗水平

记录治疗过程中不良反应发生情况。结果:治疗后

治疗组患者月经后期、卵巢多囊变的发生率明显低于对照组

差异均有统计学意义（P <0. 05）。治疗后

治疗组患者血清LH、LH/FSH、T、INS及HOMA-IR水平与治疗前比较明显降低

差异均有统计学意义（P <0. 05）;对照组患者治疗前后血清LH、LH/FSH、T、INS及HOMA-IR水平的差异均无统计学意义（P> 0. 05）;治疗后

治疗组患者血清LH、LH/FSH、T及INS水平明显低于对照组

差异均有统计学意义（P <0. 05）。治疗期间

对照组患者的不良反应发生率为10. 0%（3/30）

而治疗组患者未见严重不良反应。结论:补肾调经方治疗肾阴虚型多囊卵巢综合征的临床疗效较好

其机制可能是通过降低患者的LH、T及INS水平

优化卵泡的生长发育环境

从而改善患者的月经周期、不孕情况。

Abstract

OBJECTIVE: To explore the clinical efficacy of Bushen Tiaojing recipe from the famous traditional Chinese medicine prescription in Shanghai in the treatment of polycystic ovary syndrome of kidney-Yin deficiency.METHODS: Totally 60 patients with polycystic ovary syndrome of kidney-Yin deficiency admitted into Shanghai Pudong New Area Hospital of Traditional Chinese Medicine from Jan. 2017 to Mar. 2019 were extracted to be divided into the treatment group and the control group according to the random number table

with 30 cases in each group. The control group was given oral Clomiphene citrate tablets

while the treatment group received Bushen Tiaojing Recipe orally. All patients were treated continuously for 6 months. Changes in clinical efficacy

luteinizing hormone（ LH）

follicle stimulating hormone（ FSH）

testosterone（ T）

fasting blood glucose（ FPG）

and insulin（ INS） levels of two groups were observed. HOMA-IR was adopted ti observe the level of insulin resistance

and adverse drug reactions of two groups were recorded. RESULTS: After treatment

the incidence of late menstruation and ovarian polycystic change in the treatment group was significantly lower than that in the control group

with statistically significant differences（ P <0. 05）. After treatment

the levels of LH

LH/FSH

INS and HOMA-IR in the treatment group were significantly lower than those before treatment

with statistically significant differences（ P < 0. 05）. There was no statistically significant difference in levels of LH

LH/FSH

INS and HOMA-IR in the control group before and after treatment（ P > 0. 05）. After treatment

levels of LH

LH/FSH

T and INS in the treatment group were significantly lower than those in the control group

with statistically significant differences（ P < 0. 05）. The incidence of adverse drug reactions was 10. 0%（ 3/30） in the control group

while no severe adverse drug reactions were observed in the treatment group. CONCLUSIONS: The clinical efficacy of Bushen Tiaojing recipe in the treatment of polycystic ovary syndrome of kidney-Yin deficiency is remarkable

its mechanism may be to reduce the patients’ LH

T and INS levels

optimize the growth and development environment of follicles

so as to improve the menstrual cycle and infertility of patients.

关键词

多囊卵巢综合征补肾调经方肾阴虚型

Keywords

Polycystic ovary syndromeBushen Tiaojing recipeKidney-Yin deficiency

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