Correlation Between Efficacy of Chemotherapy in Patients with Metastatic Colorectal Cancer and Serum Homocysteine and Tumor Markers

YANG Jing; CHEN Nina; CAO Bangwei

doi:10.14009/j.issn.1672-2124.2020.04.003

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Correlation Between Efficacy of Chemotherapy in Patients with Metastatic Colorectal Cancer and Serum Homocysteine and Tumor Markers

更新时间：2022-10-08

- Correlation Between Efficacy of Chemotherapy in Patients with Metastatic Colorectal Cancer and Serum Homocysteine and Tumor Markers
- Vol. 20, Issue 4, Pages: 394-396(2020)
- 作者机构：
  
  1. 首都医科大学附属北京友谊医院肿瘤中心
  2. 首都医科大学附属北京潞河医院肿瘤中心
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.04.003
  CLC： R735.34
- Published：2020，
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[1]杨婧,陈妮娜,曹邦伟.血清同型半胱氨酸、肿瘤标志物与转移性结直肠癌患者化疗疗效的相关性研究[J].中国医院用药评价与分析,2020,20(04):394-396+402.

YANG Jing, CHEN Nina, CAO Bangwei. Correlation Between Efficacy of Chemotherapy in Patients with Metastatic Colorectal Cancer and Serum Homocysteine and Tumor Markers. [J]. 20(4):394-396(2020)
[1]杨婧,陈妮娜,曹邦伟.血清同型半胱氨酸、肿瘤标志物与转移性结直肠癌患者化疗疗效的相关性研究[J].中国医院用药评价与分析,2020,20(04):394-396+402. DOI： 10.14009/j.issn.1672-2124.2020.04.003.

YANG Jing, CHEN Nina, CAO Bangwei. Correlation Between Efficacy of Chemotherapy in Patients with Metastatic Colorectal Cancer and Serum Homocysteine and Tumor Markers. [J]. 20(4):394-396(2020) DOI： 10.14009/j.issn.1672-2124.2020.04.003.

摘要

目的:探讨血清同型半胱氨酸（Hcy）、肿瘤标志物与转移性结直肠癌（metastatic colorectal cancer

m CRC）患者化疗疗效的相关性。方法:选取2018年2月至2019年5月首都医科大学附属北京友谊医院肿瘤中心收治的76例m CRC患者

均确诊为结直肠癌Ⅳ期。采用m FOLFOX6方案（奥沙利铂+亚叶酸钙+5-氟尿嘧啶）联合贝伐珠单抗治疗4个周期

4个周期后进行疗效评价

并检测治疗前后血清癌胚抗原（CEA）、癌抗原199（CA199）、癌抗原125（CA125）和Hcy水平;采用有序Logistic回归分析CEA、CA199、CA125和Hcy水平变化与疗效的关系

采用Spearman相关系数法检测CEA、CA199、CA125和Hcy与疗效的相关性。结果:与治疗前比较

治疗后

部分缓解患者的CEA、CA199和Hcy水平明显降低

疾病稳定患者的CEA、Hcy水平明显升高

疾病进展患者的CA199、CA125和Hcy水平明显升高

上述差异均有统计学意义（P <0. 05）。治疗前后Hcy的差值和治疗前后CEA的差值是临床疗效的风险因素

差值越大

临床治疗效果越差

差异具有统计学意义（P <0. 05）。治疗前后CEA、CA199、CA125和Hcy水平的变化值与临床疗效的相关性由大至小排序为CEA> CA199> Hcy> CA125。结论:治疗前后血清CEA、CA199和Hcy水平的变化与m CRC患者化疗疗效相关

具有一定的临床价值。

Abstract

OBJECTIVE: To probe into the correlation between efficacy of chemotherapy in patients with metastatic colorectal cancer（ m CRC） and serum homocysteine（ Hcy） and tumor markers. METHODS: 76 patients with m CRC admitted into Beijing Friendeship Hospital Affiliated to Capital Medical University from Feb. 2018 to May 2019 were selected

all of whom were diagnosed as stage Ⅳ colorectal cancer. The therapeutic regimen of m FOLFOX6（ oxaliplatin +calcium folinate + 5-fluorouracil） combined bevacizumab was used for 4 courses of treatment

the efficacy was evaluated after treatment

the serum carcino-embryonic antigen（ CEA）

cancer antigen 199（ CA199）

cancer antigen 125（ CA125） and Hcy levels were detected before and after treatment after treatment; the relationship between changes and efficacy in CEA

CA199

CA125 and Hcy levels was analyzed by ordered logistic regression

the correlation between efficacy and CEA

CA199

CA125 and Hcy was detected by Spearman correlation coefficient method.RESULTS: Compared with before treatment

after treatment

the CEA

CA199 and Hcy levels of patients with partial remission were significantly reduced

the CEA and Hcy levels of patients in stable disease were significantly increased

and the CA199

CA125 and Hcy levels of patients in progressive disease were significantly increased

all with statistically significant differences（ P < 0. 05）. The difference in Hcy levels before and after treatment and the difference in CEA levels before and after treatment were the risk factors of clinical efficacy

the larger the difference

the worse the clinical efficacy

with statistically significant differece（ P < 0. 05）. The correlations between clinical efficacy and changes in CEA

CA199

CA125 and Hcy levels before and after treatment were ranked as CEA >CA199 > Hcy > CA125. CONCLUSIONS: Changes in serum CEA

CA199 and Hcy levels before and after treatment are related to the efficacy of chemotherapy in m CRC patients; this study has a certain clinical value.

关键词

同型半胱氨酸转移性结直肠癌CA125CEACA199

Keywords

HomocysteineMetastatic colorectal cancer（m CRC）CA125CEACA199

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