Causes of Left Atrial Appendage Thrombosis in Patients with Atrial Fibrillation During Anticoagulation with Dabigatran

LI Li; QIAN Xin; YAN Chunhong; MEI Qian; XIE Juan; ZHANG Jinhua; BIAN Yuan

doi:10.14009/j.issn.1672-2124.2020.03.032

您当前的位置：

首页 >

文章列表页 >

Causes of Left Atrial Appendage Thrombosis in Patients with Atrial Fibrillation During Anticoagulation with Dabigatran

更新时间：2022-10-08

- Causes of Left Atrial Appendage Thrombosis in Patients with Atrial Fibrillation During Anticoagulation with Dabigatran
- Vol. 20, Issue 3, Pages: 381-384(2020)
- 作者机构：
  
  1. 贵州省人民医院药剂科
  2. 福建医科大学附属协和医院药学部
  3. 四川省医学科学院·四川省人民医院，电子科技大学附属医院药学部，个体化药物治疗四川省重点实验室
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.03.032
  CLC： R541.75
- Published：2020，
扫描看全文
[1]李黎,钱鑫,严春宏,梅茜,谢娟,张进华,边原.达比加群抗凝治疗期间心房颤动患者左心耳血栓形成的原因分析[J].中国医院用药评价与分析,2020,20(03):381-384.

LI Li, QIAN Xin, YAN Chunhong, et al. Causes of Left Atrial Appendage Thrombosis in Patients with Atrial Fibrillation During Anticoagulation with Dabigatran. [J]. 20(3):381-384(2020)
[1]李黎,钱鑫,严春宏,梅茜,谢娟,张进华,边原.达比加群抗凝治疗期间心房颤动患者左心耳血栓形成的原因分析[J].中国医院用药评价与分析,2020,20(03):381-384. DOI： 10.14009/j.issn.1672-2124.2020.03.032.

LI Li, QIAN Xin, YAN Chunhong, et al. Causes of Left Atrial Appendage Thrombosis in Patients with Atrial Fibrillation During Anticoagulation with Dabigatran. [J]. 20(3):381-384(2020) DOI： 10.14009/j.issn.1672-2124.2020.03.032.

摘要

达比加群是近年来用于非瓣膜性心房颤动脑卒中预防的直接凝血酶抑制剂类新型口服抗凝血药（new oral anticoagulant

NOAC）

推荐用于无禁忌证的初始抗凝治疗患者或华法林抗凝达标不佳的患者。在临床实践中

仍偶见依从性良好的心房颤动患者在使用NOAC进行规律抗凝治疗期间有左心耳血栓（left atrial appendage thrombus

LAAT）形成。这是机体本身的原因还是药物的疗效或安全性问题值得探讨。本文就规律口服达比加群抗凝治疗期间发生LAAT形成的原因进行综述与分析

为临床诊疗提供参考。

Abstract

Dabigatran is the new oral anticoagulant（ NOAC） of direct thrombin inhibitors for the prevention of stroke derived from non-valvular atrial fibrillation in recent years

which is recommended in patients with initial anticoagulant therapy without contraindications or in patients with poor anticoagulant compliance with warfarin. In clinical practice

it is still occasionally observed that patients with atrial fibrillation with good compliance have left atrial appendage thrombus（ LAAT） formation during regular anticoagulation treatment with NOAC. Whether this is due to the body itself

the efficacy or safety of the drug still deserves the further discussion. This article reviews the causes of LAAT during regular oral anticoagulant therapy

and provides reference for clinical diagnosis and treatment.

关键词

达比加群左心耳血栓抗凝治疗

Keywords

DabigatranLeft atrial appendageThrombusAnticoagulation therapy

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Analysis of Anticoagulation Therapy for Patients with Acute Pulmonary Embolism and Exploration of Inpatient Pharmaceutical Care Mode

Related Author

HAN Xiaojuan

ZHANG Yueli

ZHAO Li

MA Yan

ZHANG Ying

HE Meng

Related Institution

Dept.of Pharmacy, Zhengzhou Central Hospital Affiliated to Zhengzhou University

Dept. of Pharmacy, China-Japan Friendship Hospital

⁰