Analysis of Adverse Drug Reactions in 925 Psychiatric Patients

QU Kankan; ZHANG Zhongdong

doi:10.14009/j.issn.1672-2124.2020.03.028

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Analysis of Adverse Drug Reactions in 925 Psychiatric Patients

更新时间：2022-10-08

- Analysis of Adverse Drug Reactions in 925 Psychiatric Patients
- Vol. 20, Issue 3, Pages: 366-368(2020)
- 作者机构：
  
  南京医科大学附属无锡精神卫生中心/无锡市同仁康复医院药学部
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.03.028
  CLC： R95
- Published：2020，
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[1]曲衎衎,张忠东.925例精神科患者的药品不良反应分析[J].中国医院用药评价与分析,2020,20(03):366-368+371.

QU Kankan, ZHANG Zhongdong. Analysis of Adverse Drug Reactions in 925 Psychiatric Patients. [J]. 20(3):366-368(2020)
[1]曲衎衎,张忠东.925例精神科患者的药品不良反应分析[J].中国医院用药评价与分析,2020,20(03):366-368+371. DOI： 10.14009/j.issn.1672-2124.2020.03.028.

QU Kankan, ZHANG Zhongdong. Analysis of Adverse Drug Reactions in 925 Psychiatric Patients. [J]. 20(3):366-368(2020) DOI： 10.14009/j.issn.1672-2124.2020.03.028.

摘要

目的:了解精神科患者药品不良反应（adverse drug reaction

ADR）发生的特点及规律

为临床安全用药提供理论依据。方法:对2015年1月—2019年8月无锡市精神卫生中心上报的925例发生ADR的精神科患者资料进行统计分析

分析患者基本资料、主要怀疑药品及其分类、ADR累及器官和（或）系统及主要临床表现、ADR因果关联性及转归等。结果:925例发生ADR的精神科患者中

>60岁患者所占比例最高（323例

占34. 92%）;患者的原患疾病以精神分裂症为主（562例

占60. 76%）。主要怀疑药品共引发ADR共1 044例次

以抗精神病药为主

其中奥氮平致ADR例次数所占比例最高（171例次

占16. 38%）。ADR共累及器官和（或）系统1 072例次

主要累及神经系统（239例次

占22. 29%）

临床表现以锥体外系病为主。经过治疗

925例发生ADR的患者中

好转587例

占63. 46%。结论:临床应加强对精神科患者的用药监测

出现ADR后应及时减量、停药

以确保患者用药安全、有效。

Abstract

OBJECTIVE: To investigate the characteristics and regularities of adverse drug reactions（ ADR）occurred in psychiatric patients

so as to provide theoretical references for clinical safe medication. METHODS: Data of ADR cases in 925 psychiatric patients reported from Jan. 2015 to Aug. 2019 were collected and analyzed in terms of patients’ general information

main suspected drugs and its classification

ADR involved organs and（ or） systems and main clinical manifestation

the causal correlation and outcomes. RESULTS: Among the 925 psychiatric patients with ADR

mostly were aged > 60（ 323 cases

34. 92%）; the primary diseases of patients were mainly schizophrenia（ 562 cases

60. 76%）. The main suspected drugs had induced 1 044 case-times of ADR

mainly concentrated in antipsychotic drugs

of which olanzapine had induced the most ADR（ 171 case-timss

16. 38%）. There were 1 072 case-times of ADR involved organs and（ or） systems

mainly involved the neurological system（ 239 case-times

22. 29%）

and the clinical manifestations were mainly extrapyramidal diseases. Of the 925 patients with ADR

587 patients turned better after treatment

including 63. 46%. CONCLUSIONS: Medication monitoring on psychiatric patients should be strengthened

dosage reduction and drug withdrawl should be timely conducted when ADR occurred to ensure safe and effective medication.

关键词

精神科药品不良反应用药安全

Keywords

PsychiatryAdverse drug reactionsMedication safety

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