Literature Analysis of Adverse Drug Reactions Induced by Biphenyl Dimethyl Dicarboxylate

WANG Wen’e; YANG Shuang; XU Xiaoli; ZHOU Wei

doi:10.14009/j.issn.1672-2124.2020.03.027

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Literature Analysis of Adverse Drug Reactions Induced by Biphenyl Dimethyl Dicarboxylate

更新时间：2022-10-08

- Literature Analysis of Adverse Drug Reactions Induced by Biphenyl Dimethyl Dicarboxylate
- Vol. 20, Issue 3, Pages: 363-365(2020)
- 作者机构：
  
  西安交通大学医学院第一附属医院药学部
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.03.027
  CLC： {G353};R969
- Published：2020，
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[1]王文娥,杨爽,许晓丽,周伟.联苯双酯相关不良反应文献分析[J].中国医院用药评价与分析,2020,20(03):363-365.

WANG Wen’e, YANG Shuang, XU Xiaoli, et al. Literature Analysis of Adverse Drug Reactions Induced by Biphenyl Dimethyl Dicarboxylate. [J]. 20(3):363-365(2020)
[1]王文娥,杨爽,许晓丽,周伟.联苯双酯相关不良反应文献分析[J].中国医院用药评价与分析,2020,20(03):363-365. DOI： 10.14009/j.issn.1672-2124.2020.03.027.

WANG Wen’e, YANG Shuang, XU Xiaoli, et al. Literature Analysis of Adverse Drug Reactions Induced by Biphenyl Dimethyl Dicarboxylate. [J]. 20(3):363-365(2020) DOI： 10.14009/j.issn.1672-2124.2020.03.027.

摘要

目的:探讨联苯双酯所致药品不良反应（adverse drug reaction

ADR）的一般规律及特点

为临床合理用药提供参考。方法:检索中国知网数据库、维普中文科技期刊数据库和万方数据库从建库至2019年6月国内医药期刊公开发表的联苯双酯致ADR的个案报道文献

对相关数据进行统计分析。结果:共收集到联苯双酯致ADR的个案报道文献20篇

获取ADR有效病例47例

48例次。31例报告了性别、年龄的患者中

男性患者所占比例高于女性患者[83. 87%（26例） vs. 16. 13%（5例）];> 20～50岁患者居多（21例

占67. 74%）;原患疾病以各型肝炎为主; ADR发生时间以给药后>7～14 d为主; ADR累及器官和（或）系统以肝胆系统为主

临床表现主要为氨基转移酶升高和黄疸。经停药、对症治疗

患者预后良好

无死亡病例报告。结论:联苯双酯的临床应用广泛且价格便宜

但使用时应严格把握适应证

加强用药监测

保证安全、有效、经济用药。

Abstract

OBJECTIVE: To probe into the general regularities and characteristics of adverse drug reactions（ ADR） induced by biphenyl dimethyl dicarboxylate

so as to provide reference for clinical rational drug application.METHODS: CNKI

VIP and Wanfang database were retrieved for case reports of ADR induced by biphenyl dimethyl dicarboxylate published on domestic medical journals from base-building to Jun. 2019

the retrieved data were collected and analyzed. RESULTS: A total of 20 case reports of ADR induced by biphenyl dimethyl dicarboxylate were collected

47 effective ADR cases were obtained

including 48 case-times. Among the 31 cases who reported gender and age of patients

the percentage of male patients was higher than that of female patients [83. 87%（ 26 cases） vs.16. 13%（ 5 cases） ]; most patients were aged > 20 to 50 years（ 21 cases

67. 74%）; the primary diseases were mainly various types of hepatitis; ADR occurred mainly at >7 ～ 14 d after administration; the ADR involved organs and（ or） systems were mainly hepatobiliary system

with the clinical manifestation were mainly aminotransferases rise and jaundice. After drug withdrawl and symptomatic treatment

patient’s prognosis was good and no deaths were reported.CONCLUSIONS: Biphenyl dimethyl dicarboxylate has a wide range of clinical applications and cheap price

but its indications should be strictly controlled during application

and drug monitoring should be strengthened to ensure safe

effective and economical medication.

关键词

联苯双酯药品不良反应文献分析

Keywords

Biphenyl dimethyl dicarboxylateAdverse drug reactionsLiterature analysis

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