Reports of 221 Cases of Adverse Drug Reactions

LIU Liya; SONG Shaolian; CHU Ning; YANG Xixiao

doi:10.14009/j.issn.1672-2124.2020.03.026

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Reports of 221 Cases of Adverse Drug Reactions

更新时间：2022-10-08

- Reports of 221 Cases of Adverse Drug Reactions
- Vol. 20, Issue 3, Pages: 358-362(2020)
- 作者机构：
  
  南方医科大学深圳医院药剂科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.03.026
  CLC： R95
- Published：2020，
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[1]刘丽亚,宋少练,储宁,杨西晓.221例药品不良反应报告[J].中国医院用药评价与分析,2020,20(03):358-362.

LIU Liya, SONG Shaolian, CHU Ning, et al. Reports of 221 Cases of Adverse Drug Reactions. [J]. 20(3):358-362(2020)
[1]刘丽亚,宋少练,储宁,杨西晓.221例药品不良反应报告[J].中国医院用药评价与分析,2020,20(03):358-362. DOI： 10.14009/j.issn.1672-2124.2020.03.026.

LIU Liya, SONG Shaolian, CHU Ning, et al. Reports of 221 Cases of Adverse Drug Reactions. [J]. 20(3):358-362(2020) DOI： 10.14009/j.issn.1672-2124.2020.03.026.

摘要

目的:探讨南方医科大学深圳医院（以下简称"我院"）药品不良反应（adverse drug reaction

ADR）发生的规律及特点

为临床安全用药提供参考。方法:收集2016—2018年我院监测与上报的ADR报告221例

对ADR类型、患者性别及年龄、涉及药物类别、给药途径、ADR累及器官和（或）系统及ADR的关联性分析及预后等进行统计分析。结果:2016—2018年

我院上报的ADR病例数逐年增长。221例ADR中

一般的ADR居多

共137例（占61. 99%）;男性患者（127例

占57. 47%）多于女性患者（94例

占42. 53%）;>60～70岁年龄段发生ADR的患者居多; ADR涉及14类药物、76个品种;引发ADR病例数最多的药物为抗感染药

其次为诊断用药（造影剂）;静脉给药是发生ADR最主要的途径

其次为口服给药; ADR主要累及皮肤及其附件

其次为消化系统;严重的ADR有29例

其中11例（占37. 93%）由抗感染药引起; 67例新的ADR中

24例由抗感染药导致;经停药及对症处理后

大部分患者的ADR好转。结论:ADR的发生与药物类别、给药途径及患者年龄等多种因素有关

医务人员应重视ADR监测

促进临床安全用药。

Abstract

OBJECTIVE: To probe into the regularities and characteristics of adverse drug reactions（ ADR）occurred in Shenzhen Hospital of Southern Medical University（ hereinafter referred to as "our hospital"）

so as to provide references for clinical safe medication. METHODS: 221 cases of ADR monitored and reported in our hospital during 2016-2018 were collected and analyzed in terms of types of ADR

patients’ gender and age

categories of involved drugs

ADR involved organs and（ or） systems

correlation analysis and prognosis. RESULTS: During 2016-2018

the number of reported ADR in our hospital had increased year by year. Among the 221 cases of ADR

mostly were general ADR

including 137 cases（ 61. 99%）; the number of male patients（ 127 cases

57. 47%） was more than that of female patients（ 94 cases

42. 53%）; most patients were aged between > 60-70; 76 varieties of 14 categories of drugs were involved; anti-infectious drugs had induced the most ADR cases

followed by diagnostic drugs（ contrast agents）; intravenous administration was the main route inducing ADR

followed by oral administration; the ADR mainly involved skin and its accessories

followed by digestive system; there were 29 cases of severe ADR

of which 11 cases（ 37. 93%） were induced by anti-infectious drugs; of the 67 new ADR cases

24 cases were induced by anti-infectious drugs; most patients turned better after drug withdrawl and symptomatic treatment. CONCLUSIONS: The occurrence of ADR is related to multiple factors

including categories of drugs

administration routs and patients’ age

medical staff should pay attention to ADR monitoring to promote safe clinical medication.

关键词

药品不良反应用药安全分析

Keywords

Adverse drug reactionMedication safetyAnalysis

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