OBJECTIVE: To explore the application rationality of Lianbizhi injection in children and the drug utilization of traditional Chinese medicine injection in children. METHODS: Retrospective analysis was conducted on clinical data of hospitalized children with Lianbizhi injection in a children’s hospital in 2018. Combined with the drug instructions

age and body mass of the children

dose

concentration and frequency of administration

solvent selection were statistically analyzed. The drug utilization index was calculated to explore the rational evaluation method of traditional Chinese medicine injection in children. RESULTS: Totally 1 549 children were enrolled

the average rationality score was 5. 43. And the compliance rate of indications was the lowest

only 45. 32%（ 702/1 549）. The mean dose concentration exceeded the prescribed range（ 0. 8-1. 5 g/L）

the minimum concentration was 0. 2 g/L

and the maximum concentration was 6. 25 g/L. Children’s drug use index-dose（ cd DUI） >1. 1 was found in children aged from 0 to 1 years

while cd DUI<0. 9 was found in children aged over 4 years. Children’s drug use index-concentration（ cc DUI） in children of different ages were all>1

especially those aged ≤6 months. The drug use index（ c DUI） of children with body mass ≤30 kg was all > 1. 1

while the c DUI of children with body mass > 30 kg were all < 0. 9.CONCLUSIONS: It can be seen from the age

body mass

average dose and drug utilization index that children with lower age or lower body mass have a large dose of Lianbizhi injection

while children with higher age or higher body mass have a low dose of Lianbizhi injection

and the drug concentration is too high. Therefore

the application rationality of traditional Chinese medicine injections in children should be strengthened.