OBJECTIVE: To compare the chemical composition differences between Qinlian Xietong formula granules and traditional decoction pieces

so as to probe into the clinical application prospects of formula granules.METHODS: Ultra-high performance liquid chromatography was adopted

15 reference materials such as puerarin

daidzein

baicalin

tetrahydropalmatine

berberine hydrochloride and ammonium glycyrrhizinate were set as the reference substance

the chemical composition differences between the 75% methanol solution extracts of Qinlian Xietong formula granules an the traditional decoction pieces were compared. RESULTS: The results of chromatographic peak separation of reference substance and test samples were good. The method had good specificity

reproducibility and stability. The differences of ultra-high performance liquid chromatography between Qinlian Xietong formula granules and the traditional decoction was not remarkable. The component uniformity of Qinlian Xietong formula granules was good. CONCLUSIONS: The chemical composition differences between Qinlian Xietong formula granules and the traditional decoction was not significant.