Effects of Butylphthalide and Sodium Chloride Injection Combined with Citicoline Sodium Injection on Neurological Function and JAK2/STAT3 Signal Transduction Pathway in Elderly Patients with Cerebral Infarction

HAN Yuhui; YANG Yaling; LU Wusheng

doi:10.14009/j.issn.1672-2124.2020.03.012

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Effects of Butylphthalide and Sodium Chloride Injection Combined with Citicoline Sodium Injection on Neurological Function and JAK2/STAT3 Signal Transduction Pathway in Elderly Patients with Cerebral Infarction

更新时间：2022-10-08

- Effects of Butylphthalide and Sodium Chloride Injection Combined with Citicoline Sodium Injection on Neurological Function and JAK2/STAT3 Signal Transduction Pathway in Elderly Patients with Cerebral Infarction
- Vol. 20, Issue 3, Pages: 304-307(2020)
- 作者机构：
  
  中国人民解放军联勤保障部队第九○九医院/厦门大学附属东南医院神经内科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.03.012
  CLC： R743.33
- Published：2020，
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[1]韩玉惠,杨雅玲,卢武生.丁苯酞氯化钠注射液联合胞磷胆碱钠注射液对老年脑梗死患者神经功能及JAK2/STAT3信号转导通路的影响[J].中国医院用药评价与分析,2020,20(03):304-307+311.

HAN Yuhui, YANG Yaling, LU Wusheng. Effects of Butylphthalide and Sodium Chloride Injection Combined with Citicoline Sodium Injection on Neurological Function and JAK2/STAT3 Signal Transduction Pathway in Elderly Patients with Cerebral Infarction. [J]. 20(3):304-307(2020)
[1]韩玉惠,杨雅玲,卢武生.丁苯酞氯化钠注射液联合胞磷胆碱钠注射液对老年脑梗死患者神经功能及JAK2/STAT3信号转导通路的影响[J].中国医院用药评价与分析,2020,20(03):304-307+311. DOI： 10.14009/j.issn.1672-2124.2020.03.012.

HAN Yuhui, YANG Yaling, LU Wusheng. Effects of Butylphthalide and Sodium Chloride Injection Combined with Citicoline Sodium Injection on Neurological Function and JAK2/STAT3 Signal Transduction Pathway in Elderly Patients with Cerebral Infarction. [J]. 20(3):304-307(2020) DOI： 10.14009/j.issn.1672-2124.2020.03.012.

摘要

目的:探讨丁苯酞氯化钠注射液联合胞磷胆碱钠注射液对老年脑梗死（cerebral infarction

CI）患者神经功能及JAK2/STAT3信号转导通路的影响。方法:选取2017年3月至2019年5月中国人民解放军联勤保障部队第九○九医院收治的老年CI患者60例

采用简单随机化分组方法分为观察组和对照组

每组30例。两组患者均给予常规治疗

在此基础上

对照组患者给予胞磷胆碱钠注射液治疗

观察组患者给予丁苯酞氯化钠注射液联合胞磷胆碱钠注射液治疗。观察两组患者临床疗效

治疗前后神经功能[美国国立卫生院卒中神经功能缺损评分量表（national institutes of health stroke scale

NIHSS）评分]、日常生活能力（Barthel指数）及血液流变学指标变化

血清脑源性神经营养因子（BDNF）、神经元特异性烯醇化酶（NSE）、谷胱甘肽过氧化物酶（GSHPx）、总抗氧化能力（T-AOC）及JAK2/STAT3信号转导通路相关蛋白表达水平。结果:观察组患者的总有效率为90. 00%（27/30）

明显高于对照组的66. 67%（20/30）

差异有统计学意义（P<0. 05）。治疗后

观察组患者NIHSS评分明显低于对照组

Barthel指数明显高于对照组

差异均有统计学意义（P<0. 05）;治疗后

观察组患者血浆黏度、全血黏度、血小板聚集率及纤维蛋白原水平明显低于对照组

血清BDNF、NGF、GSH-Px及T-AOC水平明显高于对照组

差异均有统计学意义（P<0. 05）;治疗后

观察组患者JAK2、P-JAK2及P-STAT3表达水平明显低于对照组

差异均有统计学意义（P<0. 05）。结论:丁苯酞氯化钠注射液联合胞磷胆碱钠注射液治疗老年CI的疗效显著

能有效改善患者神经功能

提高日常生活能力

可能与该方案能进一步改善血液流变学、缓解氧化应激反应及提高脑保护效果有关。

Abstract

OBJECTIVE: To probe into the effects of butylphthalide and sodium chloride injection combined with citicoline sodium injection on neurological function and JAK2/STAT3 signal transduction pathway in elderly patients with cerebral infarction（ CI）. METHODS: 60 elderly patients with CI admitted into No. 909 Hospital of Joint Logistic Support Force of PLA from Mar. 2017 to May 2019 were selected and divided into observation group and control group via simple randomized grouping method

with 30 cases in each group. Both groups were given conventional treatment

on this basis

the control group was treated with citicoline sodium injection

while the observation group was given butylphthalide and sodium chloride injection combined with citicoline sodium injection. The clinical efficacy

changes in neurological function [National Institutes of Health Stroke Scale（ NIHSS） score]

activity of daily living（ Barthel index） and hemorheology indices

serum brain-derived neurotrophic factor（ BDNF）

neuron specific enolase（ NSE）

glutathione peroxidase（ GSH-Px）

total antioxidant capacity（ T-AOC） and JAK2/STAT3 signal transduction pathway related protein expression levels of the two groups before and after treatment were observed. RESULTS: The total effective rate of observation group was 90. 00%（ 27/30）

which was significantly higher than that of the control group（ 66. 67%

20/30）

with statistically significant difference（ P < 0. 05）. After treatment

the NIHSS score of observation group was significantly lower than that of the control group

while the Barthel index was significantly higher than that of the control group

with statistically significant differences（ P<0. 05）; after treatment

the plasma viscosity

whole blood viscosity

platelet aggregation rate and fibrinogen of observation group were significantly lower than those of the control group

while the serum BDNF

NGF

GSH-Px and T-AOC levels were significantly higher than those of the control group

with statistically significant differences（ P<0. 05）; after treatment

the expression levels of JAK2

P-JAK2 and P-STAT3 of observation group were significantly lower than those of the control group

with statistically significant differences（ P < 0. 05）. CONCLUSIONS: The efficacy of butylphthalide and sodium chloride injection combined with citicoline sodium injection in treatment of elderly patients with CI is remarkable

it can effectively improve patients’ neurological function and activity of daily living

which may be related that the therapeutic regimen can further improve blood rheology

relieve oxidative stress response and improve brain protection effect.

关键词

丁苯酞氯化钠注射液胞磷胆碱钠注射液脑梗死神经功能JAK2/STAT3信号转导通路总抗氧化能力

Keywords

Butylphthalein and sodium chloride injectionCiticoline sodium injectionCerebral infarctionNeurological functionJAK2/STAT3 signal transduction pathwayTotal antioxidant capacity

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