Systematic Evaluation of Biejiajian Pills Combined with Entecavir in the Treatment of Hepatitis B Cirrhosis

JIANG Yinxiao; XU Min; CHENG Huizhen; LIU Huan; PENG Xi; LI Haotian; WEI Shizhang; MA Xiao

doi:10.14009/j.issn.1672-2124.2020.03.003

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Systematic Evaluation of Biejiajian Pills Combined with Entecavir in the Treatment of Hepatitis B Cirrhosis

更新时间：2022-10-08

- Systematic Evaluation of Biejiajian Pills Combined with Entecavir in the Treatment of Hepatitis B Cirrhosis
- Vol. 20, Issue 3, Pages: 268-272(2020)
- 作者机构：
  
  1. 成都中医药大学药学院,中药材标准化教育部重点实验室
  2. 解放军总医院第五医学中心药学部
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.03.003
  CLC： R512.62;R575.2
- Published：2020，
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[1]蒋吟啸,许敏,程慧珍,刘欢,彭希,李浩田,魏士长,马骁.鳖甲煎丸联合恩替卡韦治疗乙型肝炎肝硬化的系统评价[J].中国医院用药评价与分析,2020,20(03):268-272+279.

JIANG Yinxiao, XU Min, CHENG Huizhen, et al. Systematic Evaluation of Biejiajian Pills Combined with Entecavir in the Treatment of Hepatitis B Cirrhosis. [J]. 20(3):268-272(2020)
[1]蒋吟啸,许敏,程慧珍,刘欢,彭希,李浩田,魏士长,马骁.鳖甲煎丸联合恩替卡韦治疗乙型肝炎肝硬化的系统评价[J].中国医院用药评价与分析,2020,20(03):268-272+279. DOI： 10.14009/j.issn.1672-2124.2020.03.003.

JIANG Yinxiao, XU Min, CHENG Huizhen, et al. Systematic Evaluation of Biejiajian Pills Combined with Entecavir in the Treatment of Hepatitis B Cirrhosis. [J]. 20(3):268-272(2020) DOI： 10.14009/j.issn.1672-2124.2020.03.003.

摘要

目的:基于荟萃分析（Meta分析）方法

系统评价鳖甲煎丸联合恩替卡韦治疗乙型肝炎肝硬化的疗效。方法:通过检索7个中外数据库

筛选出鳖甲煎丸联合恩替卡韦治疗乙型肝炎肝硬化的临床随机对照试验文献（联合用药组患者联合应用鳖甲煎丸与恩替卡韦治疗

对照组患者单纯使用恩替卡韦治疗）。运用Rev Man 5. 3软件进行Meta分析

评价偏倚风险

并对联合用药的疗效进行分析。结果:本研究共纳入9篇文献

涉及768例患者

对相关肝功能和肝纤维化指标进行了Meta分析。结果显示

当疗程≤6个月时

鳖甲煎丸联合恩替卡韦治疗可以显著降低乙型肝炎肝硬化患者的丙氨酸氨基转移酶（ALT）、总胆红素（TBIL）水平

与单纯使用恩替卡韦治疗的差异均有统计学意义（P<0. 05）;但两种方案调节天门冬氨酸氨基转移酶（AST）水平的效果比较

差异无统计学意义（P>0. 05）。当疗程为12个月时

鳖甲煎丸联合恩替卡韦治疗可显著降低AST、TBIL水平

与单纯使用恩替卡韦治疗的差异均有统计学意义（P<0. 05）;但两种方案调节ALT水平的效果比较

差异无统计学意义（P>0. 05）。两种方案调节白蛋白水平的效果比较

差异无统计学意义（P>0. 05）。同时

鳖甲煎丸联合恩替卡韦治疗还能显著降低透明质酸、透明质酸酶、层粘连蛋白、Ⅲ型前胶原和Ⅳ型胶原等肝纤维化指标水平

与单纯使用恩替卡韦治疗的差异均有统计学意义（P<0. 05）。结论:相对于单纯使用恩替卡韦治疗

鳖甲煎丸联合恩替卡韦治疗乙型肝炎肝硬化的疗效满意。

Abstract

OBJECTIVE: To systematically evaluate the efficacy of Biejiajian pills combined with entecavir in the treatment of hepatitis B cirrhosis based on Meta-analysis. METHODS: Seven Chinese and foreign databases were retrieved to collect the clinical randomized controlled trials of Biejiajian pills combined with entecavir in the treatment of hepatitis B cirrhosis（ the combination group was treated with Biejiajian pills combined with entecavir

while the control group received entecavir）. Meta-analysis was performed by using Rev Man 5. 3 software to evaluate the risk of bias and to analyze the efficacy of drug combination. RESULTS: Totally 9 literature were collected

including 768 patients. Meta-analysis was conducted on related liver function and liver fibrosis indicators. When the course of treatment was less than 6 months

compared with entecavir alone

Biejiajian pills combined with entecavir can significantly reduce the levels of alanine aminotransferase（ ALT） and total bilirubin（ TBIL） in patients with hepatitis B cirrhosis

the differences were statistically significant（ P<0. 05）; however

there was no significant difference in the effects of two regimens in regulating the levels of aspartate aminotransferase（ AST）（ P > 0. 05）. When the course of treatment was 12 months

compared with entecavir alone

Biejiajian pills combined with entecavir could significantly reduce the levels of AST and TBIL

and there were statistically significant differences（ P<0. 05）; however

there was no statistically significant difference in the effects of two regimens in regulating the levels of ALT（ P > 0. 05）. There was no significant difference in the effects of two regimens in regulating the levels of albumin（ P>0. 05）. Meanwhile

Biejiajian pills combined with entecavir treatment could also significantly reduce the levels of liver fibrosis indicators such as hyaluronic acid

hyaluronidase

laminin

type Ⅲ procollagen and type Ⅳ collagen

which were different from those treated with entecavir alone（ P < 0. 05）. CONCLUSIONS: Compared with entecavir alone

the efficacy of Biejiajian pills combined with entecavir is more significant in the treatment of hepatic B cirrhosis.

关键词

鳖甲煎丸恩替卡韦肝硬化Meta分析

Keywords

Biejiajian pillsEntecavirCirrhosisMeta-analysis

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