Overview of Research on New-Onset Diabetes induced by Statins

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Overview of Research on New-Onset Diabetes induced by Statins

更新时间：2022-10-08

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- Overview of Research on New-Onset Diabetes induced by Statins
- Vol. 20, Issue 2, Pages: 252-256(2020)
- 作者机构：
  
  1. 河北省人民医院药学部
  2. 河北省人民医院老年二科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.02.034
  CLC： R587.1
- Published：2020，
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[1]于泽芳,李颖,贾凤姹,王娜.他汀类药物致新发糖尿病的研究概况[J].中国医院用药评价与分析,2020,20(02):252-256.

YU Zefang, LI Ying, JIA Fengcha, et al. Overview of Research on New-Onset Diabetes induced by Statins. [J]. 20(2):252-256(2020)
[1]于泽芳,李颖,贾凤姹,王娜.他汀类药物致新发糖尿病的研究概况[J].中国医院用药评价与分析,2020,20(02):252-256. DOI： 10.14009/j.issn.1672-2124.2020.02.034.

YU Zefang, LI Ying, JIA Fengcha, et al. Overview of Research on New-Onset Diabetes induced by Statins. [J]. 20(2):252-256(2020) DOI： 10.14009/j.issn.1672-2124.2020.02.034.

摘要

他汀类药物属于羟甲基戊二酰辅酶A还原酶抑制剂

除具有调节血脂的作用外

还具有抑制炎症反应、减轻血管重塑、改善血管内皮功能和稳定动脉粥样硬化斑块等多重作用

可以显著降低心血管疾病风险。他汀类药物的现代临床应用比较广泛

如已被广泛应用于冠状动脉粥样硬化性心血管疾病的一级和二级预防。而他汀类药物是否会引发糖尿病是很多医师和心血管疾病患者关注的问题。本文查阅国内外相关文献

对他汀类药物致新发糖尿病风险的现有证据及相关机制研究概况进行综述。

Abstract

Statins are hydroxymethylglutaryl coenzyme A reductase inhibitors. In addition to regulating blood lipids

stains also has multiple effects such as inhibiting inflammatory response

alleviating vascular remodeling

improving vascular endothelial function and stabilizing atherosclerotic plaque

which can significantly reduce the risk of cardiovascular disease. Statins are widely used in modern clinical practice

such as the primary and secondary prevention of coronary atherosclerotic cardiovascular diseases. Whether statins can cause diabetes is a concern for many physicians and patients with cardiovascular disease. In this paper

relevant literature at home and abroad were reviewed to analyze the existing evidence and related mechanism research on the risk of new-onset diabetes induced by statins.

关键词

他汀类药物新发糖尿病机制

Keywords

StatinsNew-onset diabetesMechanism

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