Analysis of 6 Cases of Neurological Adverse Drug Reactions Induced by Ertapenem

REN Xiaolei; ZHAN Yiqiu; ZHANG Chunyan; HUANG Jing; FENG Yufei

doi:10.14009/j.issn.1672-2124.2020.02.031

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Analysis of 6 Cases of Neurological Adverse Drug Reactions Induced by Ertapenem

更新时间：2022-10-08

- Analysis of 6 Cases of Neurological Adverse Drug Reactions Induced by Ertapenem
- Vol. 20, Issue 2, Pages: 243-245(2020)
- 作者机构：
  
  北京大学人民医院药剂科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.02.031
  CLC： R969.3
- Published：2020，
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[1]任晓蕾,詹轶秋,张春燕,黄婧,封宇飞.6例厄他培南致神经系统不良反应报告分析[J].中国医院用药评价与分析,2020,20(02):243-245.

REN Xiaolei, ZHAN Yiqiu, ZHANG Chunyan, et al. Analysis of 6 Cases of Neurological Adverse Drug Reactions Induced by Ertapenem. [J]. 20(2):243-245(2020)
[1]任晓蕾,詹轶秋,张春燕,黄婧,封宇飞.6例厄他培南致神经系统不良反应报告分析[J].中国医院用药评价与分析,2020,20(02):243-245. DOI： 10.14009/j.issn.1672-2124.2020.02.031.

REN Xiaolei, ZHAN Yiqiu, ZHANG Chunyan, et al. Analysis of 6 Cases of Neurological Adverse Drug Reactions Induced by Ertapenem. [J]. 20(2):243-245(2020) DOI： 10.14009/j.issn.1672-2124.2020.02.031.

摘要

目的:探讨厄他培南致神经系统不良反应的发生规律

为临床安全用药提供参考。方法:汇总整理2017年北京大学人民医院报告的6例厄他培南致神经系统不良反应病例

进行分析和再评价。结果:6例患者中

男性4例（占66. 67%）

女性2例（占33. 33%）

男女之比为2∶1;年龄55～92岁

平均（79. 83±13. 26）岁; 4例患者伴有肾功能不全（占66. 67%）; 6例患者在使用厄他培南后2～5 d出现神经系统不良反应

均表现为精神异常

主要包括兴奋、多语、失眠、神志淡漠、嗜睡、谵妄及幻觉等症状

均在停药后减轻、消失。结论:对于肾功能不全的老年患者

应格外关注厄他培南的药物剂量调整和相关不良反应

有效减少其给患者带来的危害。

Abstract

OBJECTIVE: To probe into the regularity of neurological adverse drug reactions induced by ertapenem

so as to provide reference for safe drug use in clinic. METHODS: Totally 6 cases of adverse drug reaction on nervous system induced by ertapenem in Peking University People’s Hospital in 2017 were summarized

analyzed and reevaluated. RESULTS: Of the 6 patients

4 were male（ 66. 67%） and 2 were female（ 33. 33%）

the male to female ratio was 2 ∶ 1. The age ranged from 55 to 92 years

with an average of（ 79. 83 ± 13. 26） years. There were4 patients with renal insufficiency（ 66. 67%）. Six patients had neurological adverse drug reactions after application of urtapenem of 2 to 5 d

all of which were manifested as mental disorders

mainly including symptoms of excitement

multilingualism

insomnia

apathy

lethargy

delirium and hallucinations. After the drug was withdrew

the symptoms were alleviated and disappeared. CONCLUSIONS: For elderly patients with renal insufficiency

special attention should be paid to the dose adjustment of ertapenem and related adverse drug reactions

so as to effectively reduce the risks to patients.

关键词

厄他培南神经系统不良反应肾功能不全

Keywords

ErtapenemNervous systemAdverse reactionRenal insufficiency

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