OBJECTIVE: To probe into the microbial limit test for three kinds of capsule preparations（ Huangshen Yisheng capsules

Qufengning capsules and Songteringling capsules）. METHODS: According to General Principles1105

1106 of Chinese Pharmacopoeia: Volume Ⅳ（ 2015 Edition）

the suitability of the total number of aerobic bacteria

mold and yeast and control bacteria was examined. RESULTS: Three kinds of hospital capsule preparations were tested for the total number of aerobic bacteria by the 1 ∶ 100 test solution plate method. The recoveries of Pseudomonas aeruginosa

Staphylococcus aureus and Bacillus subtilis were 0. The culture medium dilution method could not eliminate the bacteriostasis of the test product to the control bacteria. The results showed that when the concentration of capsule shell was diluted to 1 ∶ 200

the bacteriostasis of capsule shell was not eliminated

and the recoveries of Pseudomonas aeruginosa

Staphylococcus aureus and Bacillus subtilis were 0. After removing the capsule shells

the content of the drug can be determined by the 1 ∶20 test liquid plate method for the total number of aerobic bacteria

the total number of mold and yeast determination

and direct inoculation method was used for control bacteria inspection. CONCLUSIONS: Capsule shells can significantly inhibit the growth of microorganisms

it is recommended to pay attention to the quality and safety of capsule shells.