OBJECTIVE: To investigate the effects of Guyuan Quzhuo decoction in improving hyperphosphatemia in patients undergoing maintenance hemodialysis（ MHD）

and to explore its mechanism. METHODS: Totally 80 patients with MHD admitted into Chizhou People’s Hospital in 2018 were extracted to be divided into the observation group and the control group via the envelope method

with 40 cases in each group. The control group was given conventional treatment

while the observation group was treated with Guyuan Quzhuo decoction on the basis of the control group. Blood calcium

blood phosphorus

calcium-phosphorus product

parathyroid hormone（ PTH）

blood urea nitrogen（ BUN）

and serum creatinine（ Scr） levels of two groups were observed before and after treatment

traditional Chinese medicine（ TCM） symptom scores were recorded before and after treatment. The treatment efficacy and safety were evaluated. RESULTS: The total effective rate of the observation group was 87. 50%（ 35/40）

significantly higher than 65. 00%（ 26/40） of the control group

and the difference was statistically significant（ P <0. 05）. After treatment

the TCM symptom scores and total scores of two groups were significantly lower than those before treatment; in the observation group

the symptom scores and total scores of waist and knee weakness

fatigue

dry mouth

swelling of the limbs

amine taste in the mouth and bone pain were significantly lower than those in the control group

and the differences were statistically significant（ P <0. 05）. The levels of blood phosphorus

calciumphosphate product

PTH and Scr in the observation group were significantly lower than those before treatment and the control group after treatment

and the differences were statistically significant（ P < 0. 05）. During the treatment

no significant adverse drug reactions were observed in both groups. CONCLUSIONS: Guyuan Quzhuo decoction can be used in the treatment of hyperphosphatemia in patients undergoing MHD

which can improve the body’s calcium and phosphorus levels. The effect is definite

and the mechanism may be related to the reduction of PTH secretion and the improvement of renal function.