OBJECTIVE: To probe into the analgesia effects of Dusheng Huoxue tablets and buprenorphine transdermal patch combined with nerve block for compression fracture of thoracic vertebrae in acute stage. METHODS:Totally 190 patients with compression fracture of thoracic vertebrae in acute stage admitted into Suining Central Hospital from Jan. 2016 to May 2019 were extracted to be divided into the group A and the group B via the random number table

with 95 cases in each group. The group A was treated with Dusheng Huoxue tablets and buprenorphine transdermal patch combined with nerve block for analgesia

while the group B received nerve block combined with nonsteroidal anti-inflammatory and analgesic drugs. The pain rating index and visual analogue score（ VAS） in resting state and motion state was evaluated before treatment and after treatment of 24 h

48 h

72 h and 7 d. The incidence of adverse drug reactions was observed. RESULTS: After treatment of 48 h

72 h and 7 d

the pain rating index in the group A was significantly lower than that in the group B

with statistically significant difference（ P < 0. 05）. After treatment of 48 h

72 h and 7 d

the VAS in resting state and motion state in the group A was significantly lower than that in the group B

with statistically significant difference（ P<0. 05）. There were no obvious adverse drug reactions in group A

while there were 15 patients（ 15. 79%） with mild gastrointestinal reactions in group B. CONCLUSIONS: The analgesic effects of Dusheng Huoxue tablets and buprenorphine transdermal patch combined with nerve block on acute pain caused by compression fracture of thoracic vertebrae is definite

and the treatment is relatively safer.