Effects of Shenmai Injection on Myocardial Function and Immune Function in Patients with Postoperative Chemotherapy of Breast Cancer

ZHANG Shuping; WANG Yingchun

doi:10.14009/j.issn.1672-2124.2020.02.023

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Effects of Shenmai Injection on Myocardial Function and Immune Function in Patients with Postoperative Chemotherapy of Breast Cancer

更新时间：2022-10-08

- Effects of Shenmai Injection on Myocardial Function and Immune Function in Patients with Postoperative Chemotherapy of Breast Cancer
- Vol. 20, Issue 2, Pages: 214-217(2020)
- 作者机构：
  
  1. 河北省第七人民医院肿瘤科
  2. 河北省第七人民医院普外科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.02.023
  CLC： R737.9
- Published：2020，
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[1]张淑平,王迎春.参麦注射液对乳腺癌术后化疗患者心肌功能和免疫功能的影响[J].中国医院用药评价与分析,2020,20(02):214-217.

ZHANG Shuping, WANG Yingchun. Effects of Shenmai Injection on Myocardial Function and Immune Function in Patients with Postoperative Chemotherapy of Breast Cancer. [J]. 20(2):214-217(2020)
[1]张淑平,王迎春.参麦注射液对乳腺癌术后化疗患者心肌功能和免疫功能的影响[J].中国医院用药评价与分析,2020,20(02):214-217. DOI： 10.14009/j.issn.1672-2124.2020.02.023.

ZHANG Shuping, WANG Yingchun. Effects of Shenmai Injection on Myocardial Function and Immune Function in Patients with Postoperative Chemotherapy of Breast Cancer. [J]. 20(2):214-217(2020) DOI： 10.14009/j.issn.1672-2124.2020.02.023.

摘要

目的:探讨参麦注射液对乳腺癌术后化疗患者心肌功能和免疫功能的影响。方法:选取2014年1月至2017年11月河北省第七人民医院收治的乳腺癌患者110例

采用随机数字表法分为对照组和观察组

每组55例。对照组患者采用异环磷酰胺+表柔比星+氟尿嘧啶的化疗方案

观察组患者在对照组的基础上加用参麦注射液治疗。观察两组患者的中医症状积分、心肌功能评价指标[舒张早期/舒张晚期血流峰值速度（E/A）、左心室射血分数（LVEF）;血清肌钙蛋白Ⅰ（c TnⅠ）、肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）、总超氧化物歧化酶（SOD）、丙二醛（MDA）及还原性谷胱甘肽（GSH）]水平、免疫功能评价指标[免疫球蛋白G（Ig G）、补体C3及C4]水平及淋巴细胞亚群（CD3+、CD4+和CD8+）变化情况。结果:术后

两组患者中医症状积分、心肌功能评价指标水平、免疫功能评价指标水平及淋巴细胞亚群水平的差异均无统计学意义（P>0. 05）。化疗后1周

观察组患者中医症状积分明显低于对照组

差异有统计学意义（P<0. 05）。化疗后1周

观察组患者E/A、LVEF水平明显高于对照组;血清c TnⅠ、CK、CK-MB及MDA水平明显低于对照组

而SOD、GSH水平明显高于对照组

差异均有统计学意义（P<0. 05）。化疗后1周

观察组患者血清Ig G、C3及C4水平明显低于对照组

差异均有统计学意义（P<0. 05）。化疗后1周

观察组患者CD3+、CD4+和CD4+/CD8+水平明显高于对照组

CD8+水平明显低于对照组

差异均有统计学意义（P<0. 05）。结论:参麦注射液可改善乳腺癌术后化疗患者心肌损伤

提高机体免疫功能。

Abstract

OBJECTIVE: To probe into the effects of Shenmai injection on myocardial function and immune function in patients with postoperative chemotherapy of breast cancer. METHODS: Totally 110 patients with breast cancer admitted into the Seventh People’s Hospital of Hebei from Jan. 2014 to Nov. 2017 were extracted to be divided into the control group and the observation group via the random number table

with 55 cases in each group. The control group was given the chemotherapy regimen of ifosfamide + epirubicin + fluorouracil

while the observation group was treated with Shenmai injection on the basis of the control group. The traditional Chinese medicine（ TCM） symptom score

myocardial function evaluation index [early diastolic/advanced diastolic maximum blood flow velocity（ E/A）

left ventricular ejection fraction（ LVEF）

serum troponin Ⅰ（ cTn Ⅰ）

creatine kinase（ CK）

creatine kinase isoenzyme（ CK-MB）

total superoxide dismutase（ SOD）

malondialdehyde（ MDA） and reduced glutathione（ GSH） ]levels

immune function evaluation indicators [immunoglobulin G（ IgG）

complements C3 and C4]

levels and lymphocyte subsets（ CD3

CD4

and CD8

） of two groups were observed. RESULTS: After surgery

there were no significant difference in the TCM symptom score

myocardial function evaluation index

immune function evaluation index and lymphocyte subsets between two groups（ P

0. 05）. One week after chemotherapy

the TCM symptom score of the observation group was significantly lower than that of the control group

with statistically significant difference（ P

0. 05）. One week after chemotherapy

the levels of E/A and LVEF in the observation group were significantly higher than those in the control group

the levels of serum cTnⅠ

CK-MB and MDA in the observation group were significantly lower than those in the control group

and the differences were statistically significant（ P

0. 05）.One week after chemotherapy

the levels of serum IgG

C3 and C4 in the observation group were significantly lower than those in the control group

and the differences were statistically significant（ P

0. 05）. One week after chemotherapy

the levels of CD3+

CD4+and CD4+/CD8+in the observation group were significantly higher than those in the control group

the level of CD8+was significantly lower than that in the control group

the differences were statistically significant（ P

0. 05）. CONCLUSIONS: Shenmai injection can reduce the toxic and side effects of existing chemotherapy regimens by improving myocardial injury and enhancing immunity in patients.

关键词

参麦注射液乳腺癌化疗心肌功能免疫功能

Keywords

Shenmai injectionBreast cancerChemotherapyMyocardial functionImmune function

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Related Institution

Dept. of Breast Surgery, Qinhuangdao the First Hospital

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Dept. of Critical Care Medicine, Qinhuangdao the First Hospital

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