Study on Stability of 4 Kinds of Traditional Chinese Medicine Injections for Heat-Clearing and Detoxification Compatible with Solvents

GAN Meichan; TAN Zhenhua; ZHEN Lefeng; YANG Jiezhang; ZHOU Xinming; HUANG Dongbin

doi:10.14009/j.issn.1672-2124.2020.02.018

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Study on Stability of 4 Kinds of Traditional Chinese Medicine Injections for Heat-Clearing and Detoxification Compatible with Solvents

更新时间：2022-10-08

- Study on Stability of 4 Kinds of Traditional Chinese Medicine Injections for Heat-Clearing and Detoxification Compatible with Solvents
- Vol. 20, Issue 2, Pages: 197-199(2020)
- 作者机构：
  
  1. 江门市人民医院药剂科
  2. 江门市人民医院普外科
  3. 江门市人民医院重症医学科
  4. 江门市人民医院肿瘤科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.02.018
  CLC： R286.0
- Published：2020，
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[1]甘美婵,谭振华,甄乐锋,杨杰章,周新明,黄东彬.4种清热解毒类中药注射剂与溶剂配伍后的稳定性研究[J].中国医院用药评价与分析,2020,20(02):197-199+203.

GAN Meichan, TAN Zhenhua, ZHEN Lefeng, et al. Study on Stability of 4 Kinds of Traditional Chinese Medicine Injections for Heat-Clearing and Detoxification Compatible with Solvents. [J]. 20(2):197-199(2020)
[1]甘美婵,谭振华,甄乐锋,杨杰章,周新明,黄东彬.4种清热解毒类中药注射剂与溶剂配伍后的稳定性研究[J].中国医院用药评价与分析,2020,20(02):197-199+203. DOI： 10.14009/j.issn.1672-2124.2020.02.018.

GAN Meichan, TAN Zhenhua, ZHEN Lefeng, et al. Study on Stability of 4 Kinds of Traditional Chinese Medicine Injections for Heat-Clearing and Detoxification Compatible with Solvents. [J]. 20(2):197-199(2020) DOI： 10.14009/j.issn.1672-2124.2020.02.018.

摘要

目的:探讨4种清热解毒类中药注射剂与溶剂配伍后的稳定性。方法:以喜炎平注射液、热毒宁注射液、痰热清注射液和艾迪注射液等4种清热解毒类中药注射剂为研究对象

对调配后输液的外观、p H、不溶性微粒和主要有效成分含量的变化等指标进行测定

考察不同溶剂、放置时间及精密输液器等因素的影响。结果:4种中药注射剂稀释后在6 h内能保持较好的稳定性

采用精密输液器（5μm滤膜）可以显著减少不溶性微粒的数量

且不影响主要有效成分的含量。结论:为确保用药安全有效

临床在使用中药注射剂的过程中

应当规范临床输液调配及操作管理

避免与其他药物配伍使用;精密输液器的使用可降低由不溶性微粒造成的药品不良反应发生率。

Abstract

OBJECTIVE: To probe into the stability of 4 kinds of traditional Chinese medicine injections for heatclearing and detoxification compatible with solvents. METHODS: Four kinds of traditional Chinese medicine injections（ Xiyanping Injection

Reduning Injection

Tanreqing Injection and Aidi Injection） for heat-clearing and detoxification were selected as study objects

indices including appearance

insoluble particles and changes of main active ingredient concentration after infusion preparation were measured

the effects of different solvent

storage period and precise infusion apparatus were investigated. RESULTS: The 4 kinds of traditional Chinese medicine injections can maintain good stability within 6 hours after dilution

the utilization of precision infusion apparatus（ 5 μm filter membrane） can significantly reduce the number of insoluble particles without affecting the main active ingredients concentration. CONCLUSIONS: In order to ensure the safety and effectiveness of medication

clinical infusion preparation and operation management should be standardized during the use of traditional Chinese medicine injections

and its compatibility with other drugs should be avoid; the utilization of precision infusion apparatus can reduce the incidence of adverse drug reactions caused by insoluble particles.

关键词

清热解毒中药注射剂稳定性

Keywords

Heat-clearing and detoxificationTraditional Chinese medicine injectionStability

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