Clinical Efficacy and Safety of Anti-Platelet Aggregation Combined with Anticoagulation in Treatment of Acute Cerebral Infarction with Posterior Circulation Arterial Stenosis

WU Jing; TENG Jijun

doi:10.14009/j.issn.1672-2124.2020.02.007

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Clinical Efficacy and Safety of Anti-Platelet Aggregation Combined with Anticoagulation in Treatment of Acute Cerebral Infarction with Posterior Circulation Arterial Stenosis

更新时间：2022-10-08

- Clinical Efficacy and Safety of Anti-Platelet Aggregation Combined with Anticoagulation in Treatment of Acute Cerebral Infarction with Posterior Circulation Arterial Stenosis
- Vol. 20, Issue 2, Pages: 158-160(2020)
- 作者机构：
  
  1. 青岛大学医学院附属医院神经内科
  2. 菏泽市牡丹人民医院神经内科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.02.007
  CLC： R743.3
- Published：2020，
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[1]吴静,滕继军.抗血小板聚集联合抗凝治疗对大动脉狭窄所致急性后循环脑梗死的临床疗效及安全性研究[J].中国医院用药评价与分析,2020,20(02):158-160+165.

WU Jing, TENG Jijun. Clinical Efficacy and Safety of Anti-Platelet Aggregation Combined with Anticoagulation in Treatment of Acute Cerebral Infarction with Posterior Circulation Arterial Stenosis. [J]. 20(2):158-160(2020)
[1]吴静,滕继军.抗血小板聚集联合抗凝治疗对大动脉狭窄所致急性后循环脑梗死的临床疗效及安全性研究[J].中国医院用药评价与分析,2020,20(02):158-160+165. DOI： 10.14009/j.issn.1672-2124.2020.02.007.

WU Jing, TENG Jijun. Clinical Efficacy and Safety of Anti-Platelet Aggregation Combined with Anticoagulation in Treatment of Acute Cerebral Infarction with Posterior Circulation Arterial Stenosis. [J]. 20(2):158-160(2020) DOI： 10.14009/j.issn.1672-2124.2020.02.007.

摘要

目的:探讨阿司匹林联合氯吡格雷、阿司匹林联合低分子肝素钠两种治疗方案用于大动脉狭窄所致急性后循环脑梗死的临床疗效和安全性。方法:选取2018年4月至2019年3月青岛大学医学院附属医院收治的首次发生脑梗死且确诊为急性后循环脑梗死的患者160例

以随机数字表法分为对照组（阿司匹林+氯吡格雷）和治疗组（阿司匹林+低分子肝素钠）

每组80例。两组患者均在治疗前、治疗第7日和第14日通过美国国立卫生院卒中神经功能缺损评分量表（national institutes of health stroke scale

NIHSS）评分评估神经功能缺损程度

同时观察两组患者用药期间凝血功能变化

并记录用药期间是否有症状性颅内出血及全身脏器出血等相关并发症发生。结果:治疗第14日

两组患者血浆纤维蛋白原水平、活化部分凝血酶时间、凝血酶原时间及NIHSS评分较治疗前明显改善

差异均有统计学意义（P<0. 05）;治疗第14日

治疗组患者NIHSS评分明显低于对照组

差异有统计学意义（P<0. 05）。用药期间

对照组、治疗组患者出血事件发生率分别为2. 50%（2/80）、3. 75%（3/80）

差异无统计学意义（P>0. 05）。治疗后

治疗组患者改良RANKIN量表评分、改良Barthel指数量表评分明显优于对照组

差异均有统计学意义（P<0. 05）。结论:阿司匹林与低分子肝素钠联合治疗大动脉狭窄导致的急性后循环脑梗死的效果优于阿司匹林联合氯吡格雷

且安全性较好。

Abstract

OBJECTIVE: To probe into the clinical efficacy and safety of two different therapeutic regimens（ aspirin combined with clopidogrel

aspirin combined with low-molecular-weight heparin） via random number table in treatment of acute cerebral infarction with posterior circulation arterial stenosis. METHODS: 160 patients who were first attacked by cerebral infarction and diagnosed with acute posterior circulation cerebral infarction were admitted into Affiliated Hospital of the Medical College of Qingdao University from Apr. 2018 to Mar. 2019

which were divided into control group（ aspirin combined with clopidogrel） and treatment group（ aspirin combined with low-molecular-weight heparin） via random number table

with 80 cases in each group. Both groups were assessed for neurological deficits by the National Institutes of Health Stroke Scale（ NIHSS） before treatment and at the 7 th and 14 th days of treatment.Changes of blood coagulation function during medication was observed

and the incidences of related complications such as symptomatic intracranial hemorrhage and systemic organ bleeding during medication were recorded. RESULTS:At the 14 th days of treatment

the FIB

APTT

PT and NIHSS scores of both groups had been significantly improved

with statistically significant differences（ P<0. 05）; at the 14 th day of treatment

the NIHSS score of treatment group was significantly lower than that of the control group

with statistically significant difference（ P < 0. 05）. During medication

the incidences of bleeding events of control group and treatment groups were respectively 2. 50%（ 2/80）and 3. 75%（ 3/80）

the difference had no statistical significance（ P>0. 05）. After treatment

the scores of improved RANKING scale and improved Barthel index scale of treatment group were significantly better than those of the control group

with statistically significant differences（ P<0. 05）. CONCLUSIONS: The efficacy of aspirin combined with lowmolecular-weight heparin in treatment of acute posterior circulation cerebral infarction induced by arterial stenosis is better than that of aspirin combined with clopidogrel

with higher safety.

关键词

阿司匹林氯吡格雷低分子肝素钠急性后循环脑梗死安全性

Keywords

AspirinClopidogrelLow-molecular-weight heparinAcute posterior circulation cerebral infarctionSafety

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