Effects of Levothyroxine Sodium Tablets on Vitamin D and Bone Metabolism Indexes in Pregnant Women with Subclinical Hypothyroidism at the Second Trimester

MA Jingjing; ZHOU Xue; GUO Shuqin; LI Ben; SONG Xixi; HAO Peng; LI Zhihong

doi:10.14009/j.issn.1672-2124.2020.01.025

您当前的位置：

首页 >

文章列表页 >

Effects of Levothyroxine Sodium Tablets on Vitamin D and Bone Metabolism Indexes in Pregnant Women with Subclinical Hypothyroidism at the Second Trimester

更新时间：2022-08-15

- Effects of Levothyroxine Sodium Tablets on Vitamin D and Bone Metabolism Indexes in Pregnant Women with Subclinical Hypothyroidism at the Second Trimester
- Vol. 20, Issue 1, Pages: 92-94(2020)
- 作者机构：
  
  1. 保定市第一中心医院内分泌科
  2. 河北大学附属医院胸外科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.01.025
  CLC： R714.256
- Published：2020，
扫描看全文
[1]马静静,周雪,郭淑芹,李贲,宋茜茜,郝朋,李志红.左甲状腺素钠片对妊娠中期亚临床甲状腺功能减退症患者维生素D及骨代谢指标的影响[J].中国医院用药评价与分析,2020,20(01):92-94+100.

MA Jingjing, ZHOU Xue, GUO Shuqin, et al. Effects of Levothyroxine Sodium Tablets on Vitamin D and Bone Metabolism Indexes in Pregnant Women with Subclinical Hypothyroidism at the Second Trimester. [J]. 20(1):92-94(2020)
[1]马静静,周雪,郭淑芹,李贲,宋茜茜,郝朋,李志红.左甲状腺素钠片对妊娠中期亚临床甲状腺功能减退症患者维生素D及骨代谢指标的影响[J].中国医院用药评价与分析,2020,20(01):92-94+100. DOI： 10.14009/j.issn.1672-2124.2020.01.025.

MA Jingjing, ZHOU Xue, GUO Shuqin, et al. Effects of Levothyroxine Sodium Tablets on Vitamin D and Bone Metabolism Indexes in Pregnant Women with Subclinical Hypothyroidism at the Second Trimester. [J]. 20(1):92-94(2020) DOI： 10.14009/j.issn.1672-2124.2020.01.025.

摘要

目的:探讨左甲状腺素钠片对妊娠中期亚临床甲状腺功能减退症患者维生素D及骨代谢指标的影响。方法:回顾性选取2017年1月至2018年12月保定市第一中心医院收治的妊娠中期亚临床甲状腺功能减退症患者90例

根据是否应用左甲状腺素钠片分为治疗组和对照组

每组45例。治疗组患者采用左甲状腺素钠片治疗

且每隔4周行甲状腺功能复查;对照组患者未接受左甲状腺素钠片治疗

定期行甲状腺功能复查。比较两组患者治疗前后甲状腺功能

25-羟基维生素D[25-（OH）-D]、甲状旁腺素（PTH）、骨钙素（BGP）、Ⅰ型前胶原N端前肽（PⅠNP）及骨密度水平的差异

观察两组患者的妊娠结局。结果:治疗8周后

治疗组患者促甲状腺激素水平较治疗前明显降低

25-（OH）-D、BGP、PⅠNP及骨密度较治疗前明显升高

差异均有统计学意义（P<0. 05）;对照组患者上述指标水平较治疗前无明显变化

差异均无统计学意义（P>0. 05）;治疗组患者上述指标水平明显优于对照组

差异均有统计学意义（P<0. 05）。治疗组患者的不良妊娠结局发生率为11. 11%（5/45）

明显低于对照组的28. 89%（13/45）

差异有统计学意义（P<0. 05）。结论:左甲状腺素钠片能够有效降低妊娠中期亚临床甲状腺功能减退症患者促甲状腺激素水平

调节骨代谢、25-（OH）-D水平

从而改善妊娠结局。

Abstract

OBJECTIVE: To observe the effects of levothyroxine sodium tablets on vitamin D and bone metabolism indexes in pregnant women with subclinical hypothyroidism at the second trimester. METHODS: Totally 90 pregnant women with subclinical hypothyroidism at the second trimester admitted into the First Central Hospital of Baoding from Jan. 2017 to Dec. 2018 were extracted to be divided into the treatment group and the control group according to whether or not levothyroxine sodium tablets were used

with 45 cases in each group. The treatment group was treated with Levothyroxine sodium tablets

and patients’ thyroid function was reexamined every 4 weeks. The control group only received regular reexamination of thyroid function. Changes in thyroid function

25-hydroxyvitamin D [25-（ OH）-D]

parathyroid hormone（ PTH）

bone gla protein（ BGP）

procollagen type Ⅰ N-terminal propetide（ PⅠNP） and bone mineral density before and after treatment were compared between two groups

and pregnancy outcomes were observed.RESULTS: After treatment of 8 weeks

the levels of thyroid stimulating hormone in the treatment group were significantly lower than those before treatment

and 25-（ OH）-D

BGP

P ⅠNP and bone density were significantly higher than those before treatment

and the differences were statistically significant（ P<0. 05）. The above indicators in the control group showed no significant changes compared with those before treatment

and the differences were not statistically significant（ P>0. 05）

the above indicators in the treatment group were significantly better than those in the control group

with statistically significant differences（ P<0. 05）. The incidence of adverse pregnancy outcomes in the treatment group was 11. 11%（ 5/45）

significantly lower than that in the control group [28. 89%（ 13/45） ]

with statistically significant difference（ P < 0. 05）. CONCLUSIONS: Levothyroxine sodium tablets can effectively reduce TSH levels in patients with subclinical hypothyroidism at the second trimester

regulate bone metabolism and 25-（ OH）-D levels

so as to pregnancy outcomes.

关键词

左甲状腺素钠片妊娠亚临床甲状腺功能减退症维生素D骨代谢

Keywords

Levothyroxine sodium tabletsPregnancySubclinical hypothyroidismVitamin DBone metabolism

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Efficacy and Mechanism of Fuyuan Huoxue Decoction Combined with Percutaneous Vertebroplasty in the Treatment of Fresh Vertebral Compression Fractures

Effects of Gukang Capsules Combined with Alendronate Sodium on Bone Healing and Bone Metabolism in Patients with Osteoporotic Compression Fracture After Percutaneous Kyphoplasty

Role of Vitamin D in Improving Chronic Rhinosinusitis Model Induced by Streptococcus Pneumoniae by Regulating the Imbalance of Treg/Th17 Cell Function

Effects of Osteoking on Bone Metabolism and Bone Mineral Density After Surgery of Osteoporotic Vertebral Compression Fractures

Effect of Teriparatide on Bone Mineral Density and Serum β-CTX,P1NP,OCN in Elderly Patients with Hip Fracture

Related Author

HU Sibin

LIU Daokuo

LIU Defeng

ZHAO Na

WANG Jiangjing

DENG Haifeng

ZHANG Yongbo

CHEN Shengnan

Related Institution

Dept.of Spine Surgery, Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine

Dept. of Geriatrics, Sichuan Integrative Medicine Hospital

Dept. of Orthopedics, Sichuan Integrative Medicine Hospital

Dept.of Medical Affairs, People’s Hospital of Xinjiang Uygur Autonomous Region

Dept.of Health Care, First Affiliated Hospital, School of Medicine, Shihezi University

⁰