OBJECTIVE: To probe into the efficacy of live combined bacillus subtilis and enterococcus faecium granules with multivitamines combined with blue phototherapy in treatment of neonatal jaundice. METHODS: 100 neonatal with jaundice born in the First People’s Hospital of Anqing from Feb. 2018 to Feb. 2019 were selected and divided into control group（ 48 cases） and observation group（ 52 cases） by random number table method. The control group was given continuous blue phototherapy

while the observation group was given live combined bacillus subtilis and enterococcus faecium granules with multivitamines based on the control group. Differences in clinical efficacy

related indices levels and incidences of adverse drug reactions were compared between two groups before and after treatment. RESULTS: The total effective rate of observation group was 94. 23%（ 49/52）

which was significantly higher than that of the control group（ 81. 25%

39/48）

with statistically significant difference（ P < 0. 05）. After treatment

the jaundice indices and serum total bilirubin（ TBIL） levels of both groups had been significantly decreased; the icteric indices and TBIL of observation group were significantly lower than those of the control group

and the duration of jaundice of observation group was significantly shorter than that of the control group

with statistically significant differences（ P < 0. 05）. The incidences of adverse drug reactions of observation group and control group were respectively 17. 31%（ 9/52） and 14. 58%（ 7/48）

the difference had no statistical significance（ P>0. 05）. CONCLUSIONS: The combination of live combined bacillus subtilis and enterococcus faecium granules with multivitamines and blue phototherapy in treatment of neonatal jaundice can effectively improve efficacy

lower the serum TBIL level and shorten the duration of jaundice

without increasing adverse drug reactions.