Effects of Berberine Hydrochloride Combined with Bifidobacterium Quadruple Bacteria on Infantile Infectious Diarrhea and its Influence on Intestinal Flora

CAI Xuening; FENG Sushi; SONG Duoling; LIAO Chuansheng; YANG Jilong; WU Jing; DENG Hui; MAI Xuexia

doi:10.14009/j.issn.1672-2124.2020.01.017

您当前的位置：

首页 >

文章列表页 >

Effects of Berberine Hydrochloride Combined with Bifidobacterium Quadruple Bacteria on Infantile Infectious Diarrhea and its Influence on Intestinal Flora

更新时间：2022-08-15

- Effects of Berberine Hydrochloride Combined with Bifidobacterium Quadruple Bacteria on Infantile Infectious Diarrhea and its Influence on Intestinal Flora
- Vol. 20, Issue 1, Pages: 66-68(2020)
- 作者机构：
  
  1. 南方医科大学附属何贤纪念医院/广州市番禺区何贤纪念医院小儿内科
  2. 南方医科大学附属何贤纪念医院/广州市番禺区何贤纪念医院检验科
  3. 南方医科大学附属何贤纪念医院/广州市番禺区何贤纪念医院新生儿科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.01.017
  CLC： R725.7
- Published：2020，
扫描看全文
[1]蔡学宁,冯素诗,宋多灵,廖传胜,杨基龙,吴静,邓辉,麦雪霞.盐酸小檗碱联合双歧杆菌四联活菌治疗小儿感染性腹泻的效果及对肠道菌群的影响[J].中国医院用药评价与分析,2020,20(01):66-68.

CAI Xuening, FENG Sushi, SONG Duoling, et al. Effects of Berberine Hydrochloride Combined with Bifidobacterium Quadruple Bacteria on Infantile Infectious Diarrhea and its Influence on Intestinal Flora. [J]. 20(1):66-68(2020)
[1]蔡学宁,冯素诗,宋多灵,廖传胜,杨基龙,吴静,邓辉,麦雪霞.盐酸小檗碱联合双歧杆菌四联活菌治疗小儿感染性腹泻的效果及对肠道菌群的影响[J].中国医院用药评价与分析,2020,20(01):66-68. DOI： 10.14009/j.issn.1672-2124.2020.01.017.

CAI Xuening, FENG Sushi, SONG Duoling, et al. Effects of Berberine Hydrochloride Combined with Bifidobacterium Quadruple Bacteria on Infantile Infectious Diarrhea and its Influence on Intestinal Flora. [J]. 20(1):66-68(2020) DOI： 10.14009/j.issn.1672-2124.2020.01.017.

摘要

目的:探讨盐酸小檗碱联合双歧杆菌四联活菌治疗小儿感染性腹泻的效果及对肠道菌群的影响。方法:选取2018年1月至2019年1月南方医科大学附属何贤纪念医院收治的感染性腹泻患儿150例

采用随机数字表法分为盐酸小檗碱组（采用盐酸小檗碱单独治疗）、双歧杆菌四联活菌组（采用双歧杆菌四联活菌单独治疗）和联合组（采用盐酸小檗碱和双歧杆菌四联活菌联合治疗）

每组50例。比较三组患儿的临床疗效、肠道菌群测定结果及血清白蛋白水平的差异。结果:联合组、盐酸小檗碱组和双歧杆菌四联活菌组患儿的总有效率分别为98. 00%（49/50）、84. 00%（42/50）和86. 00%（43/50）

联合组患儿的总有效率明显高于盐酸小檗碱组、双歧杆菌四联活菌组

差异均有统计意义（P<0. 05）。治疗后

联合组患儿肠道菌群测定结果、血清白蛋白水平明显优于盐酸小檗碱组、双歧杆菌四联活菌组

差异均有统计学意义（P<0. 05）。结论:盐酸小檗碱、双歧杆菌四联活菌治疗小儿感染性腹泻均有一定疗效

但两种药物联合应用效果更佳。

Abstract

OBJECTIVE: To probe into the effects of berberine hydrochloride combined with bifidobacterium quadruple bacteria on infantile infectious diarrhea and its influence on intestinal flora. METHODS: Totally 150 patients with infectious diarrhea admitted into Hexian Memorial Hospital Affiliated to Southern Medical University from Jan.2018 to Jan. 2019 were extracted to be divided into the berberine hydrochloride group（ treated with berberine hydrochloride alone）

bifidobacterium quadruple bacteria group（ treated with bifidobacterium quadruple bacteria alone）

and combined group（ treated with berberine hydrochloride combined with bifidobacterium quadruple bacteria）via the random number table

with 50 cases in each group. The clinical efficacy

results of intestinal flora determination and differences of serum albumin levels of three groups were compared. RESULTS: The total effective rates of the combined group

berberine hydrochloride group and bifidobacterium quadruple bacteria group were respectively 98. 00%（ 49/50）

84. 00%（ 42/50） and 86. 00%（ 43/50）

the total effective rates in combined group were significantly higher than that in the berberine hydrochloride group and the bifidobacterium quadruple bacteria group

with significant differences（ P<0. 05）. After treatment

the results of intestinal flora and serum albumin levels in combined group were significantly better than those in the berberine hydrochloride group and the bifidobacterium quadruple bacteria group

with significant differences（ P < 0. 05）. CONCLUSIONS: The treatment of intestinal infectious diarrhea with berberine hydrochloride and bifidobacterium quadruple bacteria can achieve certain effects

but the combined effects of the two drugs are better.

关键词

盐酸小檗碱双歧杆菌四联活菌小儿感染性腹泻肠道菌群

Keywords

Berberine hydrochlorideBifidobacterium quadruple bacteriaInfantile infectious diarrheaIntestinal flora

references

查看原文

Views

159

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effects of Umbilical Application for Strengthening Spleen and Dispelling Dampness Decoction Combined with Spinal Massage on Intestinal Mucosal Barrier Function, Intestinal Flora and Pro-Inflammatory Factors in Children with Diarrhea (Spleen Deficiency and

Efficacy of Live Combined Bifidobacterium, Lactobacillus and Enterococcus Capsules Combined with Febuxostat in the Treatment of Patients with Intermittent Gout Attack

Preliminary Study on Mechanism of Baicalin and Berberine Hydrochloride in Inhibiting Acinetobacter Baumannii Based on Metabolomics

Distribution of Intestinal Flora in Overweight Patients with Type 2 Diabetes Mellitus and Intervention Effect of Liraglutide Combined with Metformin

Effects of Berberine Hydrochloride on Trigeminal Neuralgia in Rats Based on NLRP3 Inflammatory Signaling Pathway

Related Author

FENG Hairong

LI Yuanyuan

XU Jun

WANG Ping

CHEN Xi

ZHANG Congen

ZHAO Kuijun

MA Zhijie

Related Institution

Dept.of Pediatrics, the Eighth Medical Center of PLA General Hospital

Dept.of Pediatrics, Beijing Tongzhou Maternal and Child Health Hospital

Dept.of Gastroenterology,Xinhua Hospital Chongming Branch,Shanghai Jiao Tong University School of Medicine

Dept.of Traditional Chinese Medicine Pharmacy, Beijing Friendship Hospital, Capital Medical University

Dept.of Endocrinology,the Seventh Affiliated Hospital of Xinjiang Medical University

⁰