Effects of Low Molecular Heparin on Coagulation Function,Immune Function and Antioxidant Level in Patients with Severe Pneumonia

ZENG Xuehua; QI Yongjian; LYU Xiaojing

doi:10.14009/j.issn.1672-2124.2020.01.015

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Effects of Low Molecular Heparin on Coagulation Function,Immune Function and Antioxidant Level in Patients with Severe Pneumonia

更新时间：2022-08-15

- Effects of Low Molecular Heparin on Coagulation Function,Immune Function and Antioxidant Level in Patients with Severe Pneumonia
- Vol. 20, Issue 1, Pages: 60-62(2020)
- 作者机构：
  
  江苏省中医院呼吸科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.01.015
  CLC： R563.1
- Published：2020，
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[1]曾雪华,祁永健,吕晓静.低分子肝素对重症肺炎患者凝血功能、免疫功能及抗氧化水平的影响[J].中国医院用药评价与分析,2020,20(01):60-62+65.

ZENG Xuehua, QI Yongjian, LYU Xiaojing. Effects of Low Molecular Heparin on Coagulation Function,Immune Function and Antioxidant Level in Patients with Severe Pneumonia. [J]. 20(1):60-62(2020)
[1]曾雪华,祁永健,吕晓静.低分子肝素对重症肺炎患者凝血功能、免疫功能及抗氧化水平的影响[J].中国医院用药评价与分析,2020,20(01):60-62+65. DOI： 10.14009/j.issn.1672-2124.2020.01.015.

ZENG Xuehua, QI Yongjian, LYU Xiaojing. Effects of Low Molecular Heparin on Coagulation Function,Immune Function and Antioxidant Level in Patients with Severe Pneumonia. [J]. 20(1):60-62(2020) DOI： 10.14009/j.issn.1672-2124.2020.01.015.

摘要

目的:探讨低分子肝素对重症肺炎患者凝血功能、免疫功能及抗氧化水平的影响。方法:选取2016年3月至2019年3月江苏省中医院收治的重症肺炎患者100例

采用随机数字表法分为对照组与观察组

每组50例。对照组患者给予常规治疗

观察组患者给予低分子肝素联合常规治疗。两组患者均连续治疗7 d。观察两组患者治疗前后血清纤维蛋白原（FIB）、D-二聚体（D-D）、免疫球蛋白G（Ig G）、免疫球蛋白A（Ig A）、免疫球蛋白M（Ig M）、超氧化物歧化酶（SOD）、丙二醛（MDA）、谷胱甘肽过氧化物酶（GSH-Px）、降钙素原（PCT）、肿瘤坏死因子α（TNF-α）及超敏C反应蛋白（hs-CRP）水平。结果:治疗前后

对照组患者FIB、D-D、Ig G、Ig A及Ig M水平的差异均无统计学意义（P> 0. 05）;治疗后

对照组患者SOD、GSH-Px水平较治疗前明显升高

MDA、PCT、TNF-α及hs-CRP水平较治疗前明显降低

差异均有统计学意义（P<0. 05）。治疗后

观察组患者血清FIB、D-D、MDA、PCT、TNF-α及hs-CRP水平较治疗前明显降低

Ig G、Ig A、Ig M、SOD及GSH-Px水平较治疗前明显升高

差异均有统计学意义（P<0. 05）。治疗后

观察组患者FIB、D-D、MDA、PCT、TNF-α及hs-CRP水平明显低于对照组

Ig G、Ig A、Ig M、SOD及GSH-Px水平明显高于对照组

差异均有统计学意义（P<0. 05）。结论:低分子肝素联合常规治疗用于重症肺炎的疗效显著

可显著改善患者的凝血及免疫功能

减轻氧化应激及炎症反应损伤。

Abstract

OBJECTIVE: To investigate the effects of low molecular heparin on coagulation function

immune function and antioxidant level in patients with severe pneumonia. METHODS: Totally 100 patients with severe pneumonia admitted into Jiangsu Traditional Chinese Medicine Hospital from Mar. 2016 to Mar. 2019 were extracted to be divided into the observation group and the control group via the random number table

with 50 cases in each group.The control group was given conventional treatment

while the observation group received low molecular heparin combined with conventional treatment. Both groups were treated for 7 days. Fibrinogen（ FIB）

D-dimer（ D-D）

immunoglobulin G（ IgG）

immunoglobulin A（ IgA）

immunoglobulin M（ IgM）

superoxide dismutase（ SOD）

malondialdehyde（ MDA）

glutathione peroxidase（ GSH-Px）

procalcitonin（ PCT）

tumor necrosis factor-α（ TNF-α） and high-sensitivity C-reactive protein（ hs-CRP） of two groups were observed before and after treatment.RESULTS: Before and after treatment

there was no significant difference in the levels of FIB

D-D

IgG

IgA and IgM in the control group（ P > 0. 05）. After treatment

the levels of SOD and GSH-Px in the control group were significantly higher than those before treatment

and the levels of MDA

PCT

TNF-α

and hs-CRP were significantly lower than those before treatment

the differences were statistically significant（ P<0. 05）. After treatment

the levels of FIB

D-D

MDA

PCT

TNF-α and hs-CRP in the observation group were significantly lower than those before treatment

and the levels of IgG

IgA

IgM

SOD and GSH-Px were significantly higher than those before treatment

the differences were statistically significant（ P<0. 05）. After treatment

the levels of FIB

D-D

MDA

PCT

TNF-αand hs-CRP in the observation group were significantly lower than those in the control group

the levels of IgG

IgA

IgM

SOD and GSH-Px were significantly higher than those in the control group

the differences were statistically significant（ P<0. 05）. CONCLUSIONS: The efficacy of low molecular heparin combined with conventional treatment in patients with severe pneumonia is significant

low molecular heparin can significantly improve the coagulation and immune function of patients

reduce oxidative stress and inflammatory response injury.

关键词

低分子肝素重症肺炎凝血功能免疫功能氧化应激炎症反应

Keywords

Low molecular heparinSevere pneumoniaCoagulation functionImmune functionOxidative stressInflammatory response

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