Pharmacoeconomic Evaluation of Lamotrigine and Sodium Valproate in the Treatment of Epilepsy

FU Qing; HUANG Liyun; LIN Xuejuan

doi:10.14009/j.issn.1672-2124.2020.01.012

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Pharmacoeconomic Evaluation of Lamotrigine and Sodium Valproate in the Treatment of Epilepsy

更新时间：2022-08-15

- Pharmacoeconomic Evaluation of Lamotrigine and Sodium Valproate in the Treatment of Epilepsy
- Vol. 20, Issue 1, Pages: 50-52(2020)
- 作者机构：
  
  1. 海南医学院第一附属医院药学部
  2. 海南医学院第一附属医院神经内科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2020.01.012
  CLC： R956
- Published：2020，
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[1]符青,黄丽云,林雪娟.拉莫三嗪与丙戊酸钠治疗癫痫的药物经济学评价[J].中国医院用药评价与分析,2020,20(01):50-52.

FU Qing, HUANG Liyun, LIN Xuejuan. Pharmacoeconomic Evaluation of Lamotrigine and Sodium Valproate in the Treatment of Epilepsy. [J]. 20(1):50-52(2020)
[1]符青,黄丽云,林雪娟.拉莫三嗪与丙戊酸钠治疗癫痫的药物经济学评价[J].中国医院用药评价与分析,2020,20(01):50-52. DOI： 10.14009/j.issn.1672-2124.2020.01.012.

FU Qing, HUANG Liyun, LIN Xuejuan. Pharmacoeconomic Evaluation of Lamotrigine and Sodium Valproate in the Treatment of Epilepsy. [J]. 20(1):50-52(2020) DOI： 10.14009/j.issn.1672-2124.2020.01.012.

摘要

目的:比较拉莫三嗪与丙戊酸钠治疗癫痫的药物经济学效果。方法:回顾性选取2017年6月至2018年6月海南医学院第一附属医院收治的癫痫患者100例

按照用药方式分为拉莫三嗪组与丙戊酸钠组

每组50例。拉莫三嗪组患者口服拉莫三嗪100～300 mg/d

丙戊酸钠组患者口服丙戊酸钠500～1 500 mg/d

均连续单药治疗12个月。比较两组患者的临床疗效、治疗成本及成本-效果比（C/E）的差异

并进行敏感度分析。结果:（1）拉莫三嗪组患者的总有效率为98. 0%（49/50）

明显高于丙戊酸钠组的86. 0%（43/50）;拉莫三嗪组患者的不良反应发生率为4. 0%（2/50）

明显低于丙戊酸钠组14. 0%（7/50）

差异均有统计学意义（P<0. 05）。（2）拉莫三嗪组患者的总成本、药物成本明显高于丙戊酸钠组

实验室检查成本、药品不良反应治疗成本明显低于丙戊酸钠组

差异均有统计学意义（P<0. 05）;拉莫三嗪组患者的门诊成本低于丙戊酸钠组

但差异无统计学意义（P>0. 05）。（3）两组患者C/E的差异均无统计学意义（P>0. 05）。（4）敏感性分析结果显示

拉莫三嗪组患者C/E略低于丙戊酸钠组

但差异无统计学意义（P>0. 05）。结论:拉莫三嗪与丙戊酸钠治疗癫痫的C/E相似;但拉莫三嗪的疗效更好

不良反应更少

更符合医疗用药发展的趋势。

Abstract

OBJECTIVE: To compare the pharmacoeconomics between lamotrigine and sodium valproate in the treatment of epilepsy. METHODS: Totally 100 patients with epilepsy admitted into the First Affiliated Hospital of Hainan Medical University from Jun. 2017 to Jun. 2018 were extracted to be divided into the lamotrigine group and sodium valproate group via different medication method

with 50 cases in each group. Lamotrigine group was treated with oral lamotrigine of 100-300 mg/d

and sodium valproate group received oral sodium valerodine of 500-1 500 mg/d

both groups were treated for 12 months. The clinical efficacy

treatment cost and cost-effectiveness（ C/E） of two groups were compared

and sensitivity analysis was performed. RESULTS:（ 1） The total effective rate of the lamotrigine group was 98. 0%（ 49/50）

significantly higher than the 86. 0%（ 43/50） of the valproate group; the incidence of adverse drug reactions in the lamotrigine group was 4. 0%（ 2/50）

significantly lower than the 14. 0%（ 7/50） of the valproate group

with statistically significant differences（ P<0. 05）.（ 2） The total cost and drug cost of the lamotrigine group were significantly higher than that of the valproate group

and the cost of laboratory examination and ADR treatment were significantly lower than that of the valproate group

with statistically significant differences（ P<0. 05）. The outpatient cost of lamotrigine group was lower than that of valproate group

yet the difference was not statistically significant（ P > 0. 05）.（ 3） There were no significant differences in the C/E between two groups（ P >0. 05）.（ 4） Sensitivity analysis showed that the C/E in the lamotrigine group were slightly lower than that in the valproate group

yet the difference was not statistically significant（ P > 0. 05）. CONCLUSIONS: The C/E of lamotrigine is similar to that of sodium valproate in the treatment of epilepsy. However

lamotrigine has better curative effect

fewer adverse drug reactions

and more in line with the development trend of medication.

关键词

癫痫拉莫三嗪丙戊酸钠成本-效果药物经济学

Keywords

EpilepsyLamotrigineSodium valproateCost-effectivenessPharmacoeconomics

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