Caffeine Citrate Combined with Pulmonary Surfactant and Nasal Continuous Positive Airway Pressure in the Treatment of Premature Infants with Respiratory Distress Syndrome

Wu Qi

doi:10.13407/j.cnki.jpp.1672.108X.2021.08.004

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Caffeine Citrate Combined with Pulmonary Surfactant and Nasal Continuous Positive Airway Pressure in the Treatment of Premature Infants with Respiratory Distress Syndrome

更新时间：2022-11-03

- Caffeine Citrate Combined with Pulmonary Surfactant and Nasal Continuous Positive Airway Pressure in the Treatment of Premature Infants with Respiratory Distress Syndrome
- Vol. 27, Issue 8, Pages: 14-16(2021)
- 作者机构：
  
  南京医科大学附属妇产医院,江苏,南京,210004
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672.108X.2021.08.004
  CLC：
- Published：2021，
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Wu Qi. Caffeine Citrate Combined with Pulmonary Surfactant and Nasal Continuous Positive Airway Pressure in the Treatment of Premature Infants with Respiratory Distress Syndrome. [J]. 27(8):14-16(2021)
DOI：

Wu Qi. Caffeine Citrate Combined with Pulmonary Surfactant and Nasal Continuous Positive Airway Pressure in the Treatment of Premature Infants with Respiratory Distress Syndrome. [J]. 27(8):14-16(2021) DOI： 10.13407/j.cnki.jpp.1672.108X.2021.08.004.

摘要

目的：探讨枸橼酸咖啡因在早产儿呼吸窘迫综合征（RDS）的应用价值。方法：回顾性分析我院2017年3月至2018年3月收治的190例RDS早产儿的临床资料，根据治疗方案分为对照组86例和观察组104例。对照组给予肺表面活性物质（PS）、经鼻持续气道正压通气（nCPAP）治疗，观察组给予枸橼酸咖啡因联合PS、nCPAP治疗，治疗3 d后比较分析疗效。结果：两组治疗期间均无死亡病例。观察组有效率92.31%，高于对照组的81.40%（P<0.05）；观察组机械通气时间、住院时间均短于对照组（P<0.01）；两组患儿治疗3 d后血氧分压（PaO2）、pH均升高，且观察组均高于对照组（P均<0.01），二氧化碳分压（PaCO2）均下降，且观察组低于对照组（P<0.01）；两组并发症发生率比较差异无统计学意义（P>0.05）。结论：对于早产儿RDS，应用PS、nCPAP治疗同时联合枸橼酸咖啡因可增强疗效，缩短机械通气时间和住院时间，且不会增加并发症发生率。

Abstract

Objective: To probe into the application value of caffeine citrate in premature infants with respiratory distress syndrome (RDS). Methods: Clinical data of 190 cases of premature infants with RDS admitted to our hospital from Mar. 2017 to Mar. 2018 were retrospectively analyzed and divided into the control group (n=86) and the observation group (n=104) according to different treatment regimen. The control group was given pulmonary surfactant (PS) and nasal continuous positive airway pressure (nCPAP)

while the observation group received caffeine citrate combined with PS and nCPAP. After 3 d of treatment

the efficacy of two groups was compared. Results: There were no deaths during treatment in both groups. The effective rate of the observation group was 92.31%

higher than 81.40% of the control group (P<0.05). The mechanical ventilation time and length of stay in the observation group were shorter than those in the control group (P<0.01). After 3 d of treatment

the blood oxygen partial pressure (PaO2) and pH in both groups increased

and the observation group was higher than the control group (P<0.01)

the partial pressure of carbon dioxide (PaCO2) decreased

and the observation group was lower than the control group (P<0.01). There was no significant difference in the incidence of complications between two groups (P>0.05). Conclusion: Caffeine citrate combined with PS and nCPAP in the treatment of premature infants with RDS can enhance the curative effect and shorten the mechanical ventilation time and length of stay

with no significant impacts on complications.

关键词

枸橼酸咖啡因肺表面活性物质经鼻持续气道正压通气早产儿呼吸窘迫综合征

Keywords

caffeine citratepulmonary surfactantnasal continuous positive airway pressurepremature infantsrespiratory distress syndrome

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