Objective: To probe into the effects of nalbuphine on postoperative analgesia and sedation in children with hypospadias surgery. Methods: Totally 60 children admitted into our hospital from Jun. 2017 to Dec. 2018 were divided into the nalbufine group (group N)

the tramadol group (group T) and the blank control group (group C) via the random number table

with 20 cases in each group. Fifteen minutes before the end of surgery

group N received intravenous nalbuphine 0.2 mg/kg

group T was treated with intravenous tramadol 1 mg/kg

and group C was given intravenous saline 2 mL. The clinical efficacy of three groups was analyzed. Results: The CHEOPS pain score of group N and group T was significantly lower than that of group C at 4 h (T1)

8 h (T2)

12 h (T3)

24 h (T4) and 48 h (T5) after surgery (P<0.05). The pain score of CHEOPS of group N was lower than that of group T at different time points. Ramsay sedation scores of group N were respectively (3.0±0.6) points

(2.9±0.6) points

(2.9±0.7) points

(2.7±0.6) points and (2.5±0.7) points at T1

T2

T3

T4 and T5

significantly higher than those in group T and group C (P<0.05). Ramsay scores of group T were respectively (2.1±0.5) points

(2.0±0.6) points and (2.0±0.6) at T1

T2 and T3

significantly higher than those in group C (P<0.05). There was no statistically significant difference in heart rate (HR) and blood oxygen saturation (SpO2) among three groups at different time points (P>0.05). The incidence of nausea and vomiting in group C was significantly higher than that in group N and group T (P<0.05)

and there was no statistically significant difference in the incidence of adverse drug reactions such as respiratory depression

dizziness and headache

times of patient-controlled intravenous analgesia (PCIA)

drowsiness and skin pruritus among three groups (P>0.05). Conclusion: The application of nalbuphine in hypospadias surgery in children has good analgesic and sedative effects

and the recovery period of children is stable with few adverse drug reactions.