Literature Review of Adverse drug Reactions Induced by Ceftriaxone in Children

Fan Ming

doi:10.13407/j.cnki.jpp.1672.108X.2021.03.014

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Literature Review of Adverse drug Reactions Induced by Ceftriaxone in Children

更新时间：2022-11-03

- Literature Review of Adverse drug Reactions Induced by Ceftriaxone in Children
- Vol. 27, Issue 3, Pages: 47-50(2021)
- 作者机构：
  
  上海市闵行区中心医院,上海,201199
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672.108X.2021.03.014
  CLC：
- Published：2021，
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Fan Ming. Literature Review of Adverse drug Reactions Induced by Ceftriaxone in Children. [J]. 27(3):47-50(2021)
DOI：

Fan Ming. Literature Review of Adverse drug Reactions Induced by Ceftriaxone in Children. [J]. 27(3):47-50(2021) DOI： 10.13407/j.cnki.jpp.1672.108X.2021.03.014.

摘要

目的：了解头孢曲松致儿童不良反应（ADRs）的情况，探究其发生规律。方法：检索并提取《万方数据》中有关头孢曲松引起ADRs的案例报告（1998-2018年），按年龄、性别、给药途经、原患疾病、发生时间、愈后等进行统计分析。结果：头孢曲松引起ADR以3~6岁的儿童发生较多（35.62%）；静脉滴注（97.26%）是发生ADRs的主要给药途径；累及系统/器官以全身性损害（31.51%）、肝胆系统损害（21.92%）、血小板和出血、凝血异常（12.33%）；主要临床表现为过敏性休克19例（26.03%）；发生时间多为用药后10 min（23.29%）。过敏性休克多发生于用药5 min内（36.84%）。3例（4.11%）死亡。结论：临床应重视头孢曲松在青少年及儿童中引起的ADRs，以确保用药安全。

Abstract

objective: To investigate the situation and regularity of adverse drug reaction (ADR) in children induced by ceftriaxone. Methods: Case report of ADR induced by ceftriaxone in Wanfang database from 1998 to 2018 were retrieved and extracted. Statistical analysis was conducted on age

gender

route of administration

original disease

occurrence time and recovery. Results: ADR induced by ceftriaxone was more common in children aged from 3 to 6 years (35.62%). Intravenous infusion (97.26%) was the main route of administration for ADR. Systems/organs involved were systemic damage (31.51%)

hepatobiliary system damage (21.92%)

abnormal platelets

bleeding and coagulation (12.33%). The main clinical manifestations were 19 cases of anaphylactic shock (26.03%)

the occurrence time of ADR was mostly 10 min after administration (23.29%). Anaphylactic shock mostly occurred within 5 min after administration (36.84%). There were 3 cases (4.11%) died. Conclusion: Clinical attention should be paid to ADR induced by ceftriaxone in adolescents and children to ensure medication safety.

关键词

头孢曲松儿童不良反应文献分析

Keywords

ceftriaxonechildrenadverse drug reactionsliterature review

references

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