Anti-Infective Treatment for a Case of Deep Neck Space Infection Complicated with Septic Shock by Clinical Pharmacists

Li Xuejuan; Chen Zebin; Sun Yueyu; Guo Yuxiong; Chen Wenying

doi:10.13407/j.cnki.jpp.1672.108X.2021.03.012

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Anti-Infective Treatment for a Case of Deep Neck Space Infection Complicated with Septic Shock by Clinical Pharmacists

更新时间：2022-11-03

- Anti-Infective Treatment for a Case of Deep Neck Space Infection Complicated with Septic Shock by Clinical Pharmacists
- Vol. 27, Issue 3, Pages: 40-43(2021)
- 作者机构：
  
  1. 深圳市儿童医院,广东,深圳,518038
  2. 广东省人民医院,广东,广州,510080
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672.108X.2021.03.012
  CLC：
- Published：2021，
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Li Xuejuan, Chen Zebin, Sun Yueyu, et al. Anti-Infective Treatment for a Case of Deep Neck Space Infection Complicated with Septic Shock by Clinical Pharmacists. [J]. 27(3):40-43(2021)
DOI：

Li Xuejuan, Chen Zebin, Sun Yueyu, et al. Anti-Infective Treatment for a Case of Deep Neck Space Infection Complicated with Septic Shock by Clinical Pharmacists. [J]. 27(3):40-43(2021) DOI： 10.13407/j.cnki.jpp.1672.108X.2021.03.012.

摘要

目的：探讨临床药师在颈深间隙感染并脓毒性休克患儿治疗中发挥的药学指导作用。方法：临床药师参与1例颈深间隙感染并脓毒性休克患儿的会诊。根据患儿病情特点、病原学及药敏结果，结合抗菌药物的杀菌活性、PK/PD特点以及组织分布等，将用药方案“万古霉素、亚胺培南/西司他丁钠、甲硝唑氯化钠注射液及注射用头孢曲松”调整为“青霉素G每次10万U/kg，q4h静脉滴注，利奈唑胺每次10 mg/kg，q8h静脉滴注，联合哌拉西林钠/他唑巴坦钠每次112.5 mg/kg，q8h静脉滴注”抗感染治疗。结果：医师采纳临床药师会诊建议，连续用药8 d后患儿无明显发热，10 d后患儿无发热，生命体征平稳，转至普儿科继续哌拉西林钠/他唑巴坦钠联合利奈唑胺巩固治疗12 d。整个治疗过程持续32 d，患儿感染症状基本控制，出院继续巩固治疗。结论：临床药师参与优化抗感染治疗方案，可促进抗菌药物的合理使用，提高治疗的有效率和成功率。

Abstract

Objective: To probe into the pharmaceutical guidance role of clinical pharmacists in the treatment of one child with deep neck space infection complicated with septic shock. Methods: The clinical pharmacists participated into the consultation of a child with deep cervical space infection complicated with septic shock. According to the characteristics of the child’s disease condition

etiology and drug sensitivity results

combined with the bactericidal activity of antibiotics

PK/PD characteristics and tissue distribution

the medication regimen “vancomycin

imipenem/cilastatin

metronidazole sodium chloride injection and ceftriaxone sodium for injection” was adjusted to anti-infective treatment “penicillin G 100

000 U/kg each time

q4h ivgtt

linezolid 10 mg/kg each time

q8h ivgtt

combined with piperacillin sodium/tazobactam sodium 112.5 mg/kg each time

q8h ivgtt”. Results: The clinicians adopted the suggestions of consultation by clinical pharmacists

and the child had no significant fever after 8 d of continuous medication

and there was no fever after 10 d

and the vital signs were stable. The child was transferred to the department of pediatrics for piperacillin sodium/tazobactam sodium combined with linazolid treatment for 12 d. The entire treatment process lasted for 32 d

the infection symptoms of the child were basically controlled

and the child was discharged with continuous consolidation treatment. Conclusion: The participation of clinical pharmacists in optimizing anti-infective treatment regimens can promote the rational use of antibiotics and increase the effectiveness and success rate of treatment.

关键词

颈深间隙感染脓毒性休克抗感染治疗临床药师

Keywords

eep neck space infectionseptic shockanti-infective treatmentclinical pharmacists

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