Objective: To observe the effects of aerosol inhalation of recombinant human interferon α1b on pulmonary function and levels of IFN-γ and IL-10 in children with bronchiolitis. Methods: A total of 120 children with bronchiolitis admitted into our hospital from Jan. 2017 to Jan. 2018 were extracted to be divided into the observation group and the control group via the random number table

with 60 cases in each group. The control group was given conventional symptomatic treatment

while the observation group received aerosol inhalation ofaerosol inhalation of recombinant human interferon α1b on the basis of the control group. Lung function

levels of IFN-γ and IL-10

remission of clinical symptoms before and after treatment and clinical efficacy of two groups were observed. Results: Before treatment

there were no significant differences in tidal volume (TV)

TPTEF/TE

VTPTEF /VE

PTEF and PTEF% between two groups (P>0.05). After treatment

TV

tPTEF/tE

VPTEF/VE

PTEF

and PTEF% increased in two groups compared with those before treatment (P<0.05)

and the observation group was higher than the control group (P<0.05). There was no significant difference in the levels of IFN-γ and IL-10 between two groups before treatment (P>0.05). After treatment

the levels of IFN-γ and IL-10 in two groups were significantly higher than those before treatment (P<0.05) )

and the observation group was higher than the control group

the difference was statistically significant (P<0.05). The disappearance time of clinical symptoms such as cough

wheezing

pulmonary rales and three concave signs in the observation group was shorter than that in the control group

with statistically significant difference (P<0.05). The total effective rate in the observation group was 96.67%

higher than 86.67% in the control group

and the difference was statistically significant (P<0.05). Conclusion: The clinical efficacy of aerosol inhalation of recombinant human interferon α1b in the treatment of children with bronchiolitis is significant

which can significantly shorten the course of disease

improve the clinical efficacy

and improve the pulmonary function and the levels of inflammatory factors in children.