Reduction of 6-Mercaptopurinein in Children with Acute Lymphoblastic Leukemia during Maintenance Therapy and Its Effects on Long-Term Prognosis

Guan Yujie; Han Jinfen; Zhu Yingying; Mao Yanna; Liu Wei

doi:10.13407/j.cnki.jpp.1672.108X.2021.03.003

您当前的位置：

首页 >

文章列表页 >

Reduction of 6-Mercaptopurinein in Children with Acute Lymphoblastic Leukemia during Maintenance Therapy and Its Effects on Long-Term Prognosis

更新时间：2022-11-03

- Reduction of 6-Mercaptopurinein in Children with Acute Lymphoblastic Leukemia during Maintenance Therapy and Its Effects on Long-Term Prognosis
- Vol. 27, Issue 3, Pages: 10-14(2021)
- 作者机构：
  
  1. 郑州大学附属儿童医院，河南省儿童医院，郑州儿童医院,河南,郑州,450000
  2. 新乡医学院第三附属医院,河南,新乡,453000
- 作者简介：
- 基金信息：
- DOI：10.13407/j.cnki.jpp.1672.108X.2021.03.003
  CLC：
- Published：2021，
扫描看全文
Guan Yujie, Han Jinfen, Zhu Yingying, et al. Reduction of 6-Mercaptopurinein in Children with Acute Lymphoblastic Leukemia during Maintenance Therapy and Its Effects on Long-Term Prognosis. [J]. 27(3):10-14(2021)
DOI：

Guan Yujie, Han Jinfen, Zhu Yingying, et al. Reduction of 6-Mercaptopurinein in Children with Acute Lymphoblastic Leukemia during Maintenance Therapy and Its Effects on Long-Term Prognosis. [J]. 27(3):10-14(2021) DOI： 10.13407/j.cnki.jpp.1672.108X.2021.03.003.

摘要

目的：探讨儿童急性淋巴细胞白血病（ALI）维持治疗中，依据外周白细胞、中性粒细胞计数调低巯嘌呤（6-MP）用量或停药对远期预后的影响。方法：选取2011年1月至2016年1月郑州儿童医院收治的120例ALI患儿为研究对象，依据6-MP的用量将患儿分为标准剂量治疗组、半剂量及以上治疗组、半剂量以下治疗组及停药组，比较各组毒副作用发生率及全部疗程结束2年后各组之间的临床疗效。结果：除停药组患儿复发率显著增高之外（P<0.05），另三组患儿的无病生存率、复发率、病死率比较差异无统计学意义（P>0.05）；依据白细胞及中性粒细胞计数调低或停用6-MP后，所有患儿皮疹、胃肠道反应、肝毒性、重症感染等毒副作用罕见发生。结论：依据患儿外周白细胞及中性粒细胞计数调低6-MP用量不影响患儿的远期预后，临床无明显不良反应发生，但停药可增高患儿远期复发率。

Abstract

Objective: To probe into the reduction and withdrawal of 6-mercaptopurinein (6-MP) in children with acute lymphoblastic leukemia (ALL) during maintenance therapy and its effects on long-term prognosis. Methods: From Jan. 2011 to Jan. 2016

totally 120 children with ALL admitted into Zhengzhou Children’s Hospital were extracted to be divided into the standard dose treatment group

half dose and above treatment group

half dose and below treatment group and drug withdrawal group according to different doses of 6-MP. The incidence of side effects and clinical efficacy after treatment of two years were compared. Results: Except for the significant increase of recurrence rate in the drug withdrawal group (P<0.05)

there was no significant difference in the disease-free survival rate

recurrence rate and mortality of the other three groups (P>0.05). After the reduction of white blood cells and withdrawal of 6-MP

all children had rare side effects such as rash

gastrointestinal reactions

hepatotoxicity and severe infection. Conclusion: According to the peripheral white blood cells and neutrophils count

the reduction of 6-MP does not affect the long-term prognosis of the children with ALL

and there are no significant clinical adverse drug reactions

but drug withdrawal can increase the long-term recurrence rate of the children.

关键词

急性淋巴细胞性白血病儿童6-MP预后

Keywords

acute lymphocytic leukemiachildren6-mercaptopurineprognosis

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Analysis of 36 Cases of Drug Poisoning in Children in a Grade III, Level A General Hospital andConsideration on Pharmaceutical Care

Application of Dexmedetomidine Combined with Hydromorphone Nasal Drip in Sedation of Mother-InfantSeparation before Adenoidectomy

Sirolimus in the Treatment of 5 Cases of Blue Rubber Bleb Nevus Syndrome in Children and Literature Review

Systematic Review on Efficacy and Safety of Zoledronic Acid in the Treatment of Bone Metabolic Disordersin Children

Related Author

Ding Shuxian

Ai Kui

Bian Junmei

Wang Peng

Xu Ying

Zhang Xiaoming

Zhang Shaonan

Li Changsong

Related Institution

Wuhan Third Hospital

The Second People’ s Hospital of Anhui Wuhu, Anhui Wuhu

Jiangsu Taizhou People’s Hospital, Jiangsu Taizhou

Children’s Hospital Affiliated to Zhengzhou University,Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou Key Laboratory of Children’s Digestive Diseases

Kunming Children’s Hospital / Children’s Hospital of Kunming Medical University, Kunming

⁰